Search for dissertations about: "Hematopoietic cell"
Showing result 1 - 5 of 91 swedish dissertations containing the words Hematopoietic cell.
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1. Identification of Unique Hematopoietic Stem Cell Properties
University dissertation from Lund Center for Stem Cell Biology and Cell TherapyAbstract : Hematopoietic stem cells (HSC) are sufficient and required for life long production of all blood cell lineages. Steady state HSCs are largely quiescent and we demonstrate that the kinetics of HSC cell cycling are slower compared to more committed progenitor cells also during expansion and self-renewal ex vivo and in physiological conditions. READ MORE
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2. Hematopoietic stem and progenitor cells and potentials for application in fetal cell replacement therapy
University dissertation from Dept of Obstetrics and Gynecology, Lund UniversityAbstract : Fetal cell replacement therapy or in utero hematopoietic cell transplantation (IUHCT) is proposed as a non-myeloablative alternative to bone marrow transplantation (BMT) for a number of inborn immunologic, hematologic and metabolic disorders. IUHCT represents the method through which variable amounts of natural or genetically modified hematopoietic cells can be transferred to the fetal recipient in hope of correcting the disorder and preventing postnatal permanent organ damage. READ MORE
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3. Cellular and Molecular Pathways Governing Hematopoietic Stem Cell Fate
University dissertation from Lund Center for Stem Cell Biology and Cell TherapyAbstract : Hematopoietic Stem Cells (HSCs) have been defined to have abilities of both self-renewal and multi-lineage differen-tiation. The balance between these abilities is rigorously controlled under steady-state status (homeostasis) and when the normal processes of self-renewal and differentiation become deregulated, a disorder of blood system (such as leukemias) can occur. READ MORE
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4. The role of Lhx2 in the hematopoietic stem cell function, liver development and disease
University dissertation from Umeå : MolekylärbiologiAbstract : During embryonic development, generation of functional organs is dependent on proper interactions between different cell types. Elucidation of the mechanisms operating during organ formation might provide insights into the origin of many pathological disorders in the adult. READ MORE
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5. Cardiomyocyte Cell Cycle, Renewal and Isolation
University dissertation from Cardiovascular Laboratory, Center for Stem Cell Biology, LundAbstract : Heart disease results from the loss of cardiomyocytes following myocardial damage and is a leading cause of death worldwide. Stimulating the endogenous regeneration of cardiomyocytes or isolating them from in vitro culture is an attractive therapeutic strategy. READ MORE