Search for dissertations about: "Hemoglobin adducts"

Showing result 1 - 5 of 22 swedish dissertations containing the words Hemoglobin adducts.

  2. 1. Protein adducts of hexahydrophthalic anhydride- chemical structures and biomarkers

    Author : Monica Kåredal; Avdelningen för arbets- och miljömedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; arbetsmiljömedicin; Yrkesmedicin; industrial medicine; Occupational health; nasal lavage; mass spectrometry; biomarker; human serum albumin; hemoglobin; Hexahydrophthalic anhydride; adducts;

    Abstract : Organic acid anhydrides (OAAs) are low molecular weight chemicals used in the industry for manufacturing of plastics such as epoxy resins. Exposure to these chemicals may lead to symptoms from the eyes and the respiratory tract in form of conjunctivitis, rhinitis and asthma. READ MORE

  4. 2. Metabolism and Biological Monitoring of Organic Acid Anhydrides

    Author : Christian Lindh; Avdelningen för arbets- och miljömedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rats; human; distribution; analysis; biological monitoring; autoradiography; adducts; hemoglobin; plasma; urine; Hexahydrophthalic anhydride; methyltetrahydrophthalic anhydride; guinea pigs; Occupational health; industrial medicine; Yrkesmedicin; arbetsmiljömedicin;

    Abstract : The aim of this thesis was to describe the metabolism and to develope methods for biological monitoring for two organic acid anhydrides (OAAs), namely hexahydrophthalic anhydride (HHPA) and methylhexa-hydrophthalic anhydride (MHHPA). The OAAs are reactive, low molecular weight chemicals used in vast quantities in the industry. READ MORE

  5. 3. Development of an adductomic approach to identify electrophiles in vivo through their hemoglobin adducts

    Author : Henrik Carlsson; Margareta Törnqvist; Gunnar Boysen; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Adductomics; Hemoglobin adducts; LC MS MS; Ethyl vinyl ketone; Glyoxal; Methylglyoxal; Acrylic acid; 1-Octen-3-one; Environmental Chemistry; miljökemi;

    Abstract : Humans are exposed to electrophilically reactive compounds, both formed endogenously and from exogenous exposure. Such compounds could react and form stable reaction products, adducts, at nucleophilic sites in proteins and DNA. READ MORE

  6. 4. Methodology for hemoglobin adduct measurement : Fetal exposures to acrylamide and other genotoxic agents

    Author : Hans von Stedingk; Margareta Törnqvist; Per Rydberg; Christian Lindh; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; miljökemi; Environmental Chemistry;

    Abstract : There is increasing evidence that exposure to toxic chemicals during the prenatal period constitute a higher health risk than exposure during adulthood. To characterize exposure and identify risk factors, sensitive methods for analysis of chemicals in vivo with biomarker methods are needed. READ MORE

  7. 5. Cancer Risk Assessment of Glycidol : Evaluation of a Multiplicative Risk Model for Genotoxic Compounds

    Author : Jenny Aasa; Margareta Törnqvist; Elaine M. Faustman; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; glycidol; 3-monochloropropane-1; 2-diol 3-MCPD ; genotoxicity; mutations; micronuclei; hemoglobin adducts; in vivo dose; multiplicative risk model; cancer risk assessment; human cancer risk; miljökemi; Environmental Chemistry;

    Abstract : Humans are exposed to chemical compounds in everyday life, both from the environment and from endogenous processes. Some compounds constitute a risk for cancer development. One such compound is glycidol, which is genotoxic and an animal carcinogen. It is the model compound of this work, partly due to its presence in food. READ MORE