Search for dissertations about: "HepG2 cell line"

Showing result 1 - 5 of 10 swedish dissertations containing the words HepG2 cell line.

2. 1. Single-Proton Irradiation of Living Cells - Development of New Tools for Low-Dose Radiation Research

   Author : Natalia Arteaga; Kärnfysik; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; lithography; UVL; EBL; SeACell; human hepatoma cells HepG2 ; reactive oxygen species ROS ; bystander effect; SU-8; cell recognition; cell irradiation; Single-Ion Hit Facility; low-dose; Fysicumarkivet A:2010:Arteaga Marrero;

   Abstract : A Single-Ion Hit Facility (SIHF) consists of a custom-build facility based in particle accelerators which offers irradiation controlling the number of delivered particles with a precise targeting localization. The irradiation spot can be confined down to the nanometre scale allowing the irradiation of subcellular compartments with a single particle. READ MORE

4. 2. Decellularized liver extracellular matrix as a 3D scaffold for bioengineering applications

   Author : Vamakshi Khati; Aman Russom; Håkan Jönsson; Giulia Gaudenzi; Ana Teixeira; KTH; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; liver decellularization; decellularized liver matrix bioink; bioprinting; sacrificial scaffold; viscoelasticity; bioengineering; tumor modeling; stem cell differentiation; bioreactor; Biotechnology; Bioteknologi;

   Abstract : The increasing global burden of end-stage liver disease has increased the need for liver transplantation, the definitive cure. However, there is a huge discrepancy between the number of available organ donors and the number of patients waiting for transplantation, resulting in the deaths of a significant number of patients on the waiting list as only 10% of the global need for transplantation is met. READ MORE

5. 3. The role of HIF-1alpha in epigenetic regulation of transcription

   Author : Nikola Vojnovic; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The oxygen level inside cells, determine the amount of HIF protein. By directly being involved in HIF protein turnover rates, through a mechanism, by which, oxygen is utilized as a co-factor, for the PHD enzymes, regulating HIF protein stability. READ MORE

6. 4. Regulation of insulin-like growth factor-II in human liver

   Author : Henrik von Horn; Karolinska Institutet; Karolinska Institutet; []
   Keywords : IG17-II; IGF2; IGFBPs; liver; hepatoblastoma; GH; hypoxia;

   Abstract : Insulin-like growth factors-I and -II (IGF-I and -II) are mitogens in a number of cell types and also have insulin-like actions. IGF-II has an autocrine role in a variety of malignancies; and hypoglycemia is well documented in conditions associated with elevated IGF-II precursor forms in the circulation. READ MORE

7. 5. Translational Tumor Drug Delivery : Doxorubicin formulation performance, intracellular uptake and molecular diffusion

   Author : Oliver Degerstedt; Hans Lennernäs; Erik Sjögren; Per Hansson; Jessica Rosenholm; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; doxorubicin; drug diffusion; cellular uptake; drug delivery; PBPK modelling; hepatocellular carcinoma; emulsion; IC50; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : Globally, hepatocellular carcinoma (HCC) is the most common form of liver cancer and a leading cause of cancer death. One important risk factor is liver cirrhosis and the disease progression is characterized by deposition of extracellular matrix proteins that form a fibrous network, which increases liver stiffness and may limit the effectiveness of different treatment strategies. READ MORE