Search for dissertations about: "Hippocampal slice cultures"

Showing result 1 - 5 of 6 swedish dissertations containing the words Hippocampal slice cultures.

2. 1. Mechanisms of Ischemic Brain Injury- studies in murine hippocampal slice cultures

   Author : Anna Rytter; Sektion IV; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurophysiology; Neurologi; neuropsykologi; neuropsychology; Neurology; adenosine; caspases; hypothermia; in vitro; hippocampus; ischemia; neurofysiologi;

   Abstract : Cerebral ischemia is a major cause of mortality and morbidity in the western world. Even though much effort has been put into research and development of effective drugs against ischemic damage there is to date no effective pharmacological brain protective treatment. READ MORE

4. 2. Endoplasmic Reticulum Dynamic Structural Changes in Neurons: The Fission-Fusion Phenomena

   Author : Krzysztof Kucharz; Sektion IV; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fragmentation; fission; endoplasmic reticulum; neurons; FRAP; primary cultures; organotypic slice cultures; in vivo; in situ; calcium; fusion; NMDA receptor; 2-photon microscopy; confocal microscopy;

   Abstract : The endoplasmic reticulum (ER) is crucial for protein synthesis and protein maturation, is involved in cell stress and serves in neurons as the major intracellular Ca2+ store. Neuronal ER forms a continuous network of cisterns and tubules extending from soma to a subset of dendritic spines. READ MORE

5. 3. Characterization of hippocampal slice cultures as model systems for neurodegenerative processes in Alzheimer's disease

   Author : Sara Johansson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Alzheimer's disease (AD) is the most common cause of dementia and a growing health care problem worldwide. The disease affects different brain regions, including hippocampus, enthorhinal cortex, amygdala, neocortex and certain basal forebrain nuclei. Macroscopically, shrinkage of gyri and widening of sulci characterize the AD brain. READ MORE

6. 4. N-acetylaspartate in brain - studies on efflux and function

   Author : Mattias Tranberg; Göteborgs universitet; []
   Keywords : N-acetylaspartate; Hippocampal slice cultures; HPLC; NMDA; Excitotoxicity; Volume regulation; Canavan disease;

   Abstract : N-acetylaspartate (NAA) is an amino acid derivative present in high concentration in the brain. The function of NAA is still unsettled in spite of 50 years of research. The mainly neuronal synthesis and glial breakdown of NAA requires a well regulated neuronal efflux and glial uptake. READ MORE

7. 5. Effects of aging and inflammatory molecules on the suprachiasmatic circadian clock

   Author : Mikael Nygård; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Circadian; suprachiasmatic; synaptic; inflammation; cytokine; SOCS; interferon; tumor necrosis factor; neuron; firing;

   Abstract : The suprachiasmatic nucleus (SCN) is considered the master circadian pacemaker in the mammalian brain and is vital for generating physiological and behavioral circadian rhythms. During aging and inflammatory conditions the circadian system is frequently affected, but relatively little is known about the mechanisms underlying such effects. READ MORE