Search for dissertations about: "Hollow Fiber model"

Showing result 1 - 5 of 10 swedish dissertations containing the words Hollow Fiber model.

2. 1. Methods for Preclinical Evaluation of Cytotoxic Drugs : With Special Reference to the Cyanoguanidine CHS 828 and Hollow Fiber Method

   Author : Saadia Bashir Hassan; Elin Lindhagen; Rolf Larsson; Mats O Karlsson; Mustapha Hassan; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; CHS 828; in vitro; in vivo; hollow fiber; models; NF-kB; Farmakologi; Pharmacological research; Farmakologisk forskning;

   Abstract : The novel cyanoguanidine CHS 828 has shown promising antitumor activity in many in vitro and in vivo studies. The long-term 14 days in vitro hollow fiber cultures, where tumor cells from different tumor cell lines were cultured inside semipermeable fibers, were more resistant to CHS 828 and other cytotoxic drugs than the shorter-term 3 days cultures. READ MORE

4. 2. Development of Techniques to Produce Nickel Coated Composite Materials as well as Hollow Nickel Fibres and Kinetic Study of the Process Involved

   Author : Fan Li; Sichen Du; Ioannis Arvanitidis; KTH; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Nickel; Chemical plating; Kinetics; Model; Hollow nickel fibres; Thermal decomposition; Materials science; Teknisk materialvetenskap;

   Abstract : The present thesis was mainly to study the preparation of nickel composite materials by chemical plating process. Nickel coated boron nitride particles, nickel coated spherical silica particles and nickel viscose composite fibres were prepared. Both experiment and model development were carried out to study the kinetics of the processes. READ MORE

5. 3. Analyses of Dose-Response and Mechanistic Action of Different Anti-Cancer Drugs for Neuroendocrine Tumor Cell Lines

   Author : Dhana E Larsson; Dan Granberg; Sadia Hassan; Kjell Öberg; Jens F Rehfeld; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer drugs; Screening; Hollow Fiber model; Apoptosis; Oncology; Onkologi;

   Abstract : Cancer is a disease with poor response rates on available treatments. Problems with resistance and intolerance against cancer drugs are major reasons for failure of the drugs. The need to discover new cancer drugs is important. In this thesis screening of new cancer drugs and evaluation of their mechanism of action are discussed. READ MORE

6. 4. Application of new methodology for preclinical development of anticancer drugs : With special focus on camptothecin derivatives and the cyanoguanidine CHS 828

   Author : Elin Jonsson; Uppsala universitet; []
   Keywords : Medical sciences; drug development; hollow-fiber model; FMCA; human tumour cell; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

   Abstract : This work describes the development and evaluation of new methods for preclinical anticancer drug development. The methods were specifically applied to study camptothecin analogues and the new compound CHS 828 (N-(4-chlorophenoxyhexyl)-N'-cyano-N"-4-pyridylguanidine) currently in early clinical trials. READ MORE

7. 5. Light Scattering in Fiber-based Materials : a foundation for characterization of structural properties

   Author : Tomas Linder; Stefan Andersson-Engels; Luleå tekniska universitet; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Industriell elektronik; Industrial Electronics;

   Abstract : Deeper knowledge of light propagation in fiber-based materials is fundamental in order to understand their optical appearance as well as for industrial applications. Light scattering measurements are appropriate in handling dynamic industrial environments and can provide information regarding structural properties. READ MORE