Search for dissertations about: "Human genome"

Showing result 1 - 5 of 683 swedish dissertations containing the words Human genome.

  2. 1. Genome and Transcriptome Comparisons between Human and Chimpanzee

    Author : Anna Wetterbom; Ulf Gyllensten; Lucia Cavelier; Tomas Bergström; Evan Eichler; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human; chimpanzee; genome; transcriptome; comparative studies; exon arrays; next-generation sequencing; premature termination codon; alternative splicing; primate evolution; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; Bioinformatik; Bioinformatics;

    Abstract : The chimpanzee is humankind’s closest living relative and the two species diverged ~6 million years ago. Comparative studies of the human and chimpanzee genomes and transcriptomes are of great interest to understand the molecular mechanisms of speciation and the development of species-specific traits. READ MORE

  4. 2. Human demographic history : Insights on the human past based on genomes from Southern through Central Africa

    Author : Gwenna Breton; Mattias Jakobsson; Carina Schlebusch; Per Sjödin; Paul Verdu; David Comas; Uppsala universitet; []
    Keywords : high-coverage genomes; Sub-Saharan Africa; demography; genetic admixture; population genetics; human evolutionary genetics; Khoe-San; rainforest hunter-gatherers; Biology with Specialisation in Human Evolution and Genetics; Biologi med inriktning mot människans evolution och genetik;

    Abstract : Evidence from paleontology, archaeology and population genetics support that modern humans originated in Africa. While the out-of-Africa event and subsequent colonization of all continents are well documented, human history in Africa at that time and before is less studied. READ MORE

  5. 3. Human Adipocytes : Proteomic Approaches

    Author : Åsa Jufvas; Peter Strålfors; Alexander Vener; Maria V Turkina; Hans Jörnvall; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Type 2 diabetes is characterized by increased levels of glucose in the blood originating from insulin resistance in insulin sensitive tissues and from reduced pancreatic insulin production. Around 400 million people in the world are diagnosed with type 2 diabetes and the correlation with obesity is strong. READ MORE

  6. 4. Genome Variation in Human Populations : Exploring the Effects of Demographic History and the Potential for Mapping of Complex Traits

    Author : Åsa Johansson; Ulf Gyllensten; Marta Alarcon; Andrew Clark; Uppsala universitet; []
    Keywords : Genetics; genetics; evolution; microsatellie; SNP; selection; linkage disequilibrium; haplotype; Genetik;

    Abstract : A major challenge in human genetics is to understand the genetic variation underlying common diseases. In this thesis, I focus on forces creating differences between individuals and genomic regions, methods for characterizing genomic variation, and the association between genomic and phenotypic variation. READ MORE

  7. 5. Topics in Human Gene Mapping

    Author : Azra Kurbasic; Matematisk statistik; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; actuarial mathematics; Statistik; programming; Statistics; Mathematics; Naturvetenskap; Natural science; hidden Markov model; linkage analysis; Human genome; disease gene; programmering; aktuariematematik; operationsanalys; operations research; Matematik;

    Abstract : This thesis is interdisciplinary between Mathematical Statistics, Genetics, and Medicine. It mainly consists of topics in mathematical modelling of the correlation of inheritance of genes and disease in a family, a method called linkage analysis. It is organized as follows. READ MORE