Search for dissertations about: "Huntington’s disease"

Showing result 1 - 5 of 20 swedish dissertations containing the words Huntington’s disease.

  1. 1. A peripheral immune response in Huntington's disease and delineation of its importance in disease pathology

    University dissertation from Media-Tryck

    Author : Anna Magnusson-Lind; Lunds universitet.; Lund University.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; peripheral symptoms; Huntington s disease; immune response; muscle atrophy; cytokines; gene expression; JAK STAT; NFkB; IL-6; TNF-alpha;

    Abstract : Huntington’s disease (HD) is a fatal, hereditary disease for which there is no cure. It is caused by a mutation in a gene called huntingtin. HD is a so-called neurodegenerative disease, where there is a loss of neurons in areas of the brain that control body movements. This results in uncontrolled dance-like movements (chorea). READ MORE

  2. 2. Communication breakdown - synaptic dysfunction in Huntington's disease

    University dissertation from Ruben Smith, Inst. för Experimentell Medicinsk Vetenskap, Lunds Universitet

    Author : Ruben Smith; Lunds universitet.; Lund University.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; neurodegeneration; neuropsychology; neurophysiology; Neurologi; cholinergic neuron; exocytosis; transmitter release; intracellular transport; insulin; Huntington s disease; synapse; neuropsykologi; neurofysiologi;

    Abstract : Huntington's disease (HD) is a neurodegenerative disease caused by a CAG-triplet expansion in the gene encoding the protein huntingtin. The disease typically starts in mid-life and progresses for 15-20 years. To date no effective treatment is available for curing the disease. HD primarily affects the striatum, cerebral cortex and hypothalamus. READ MORE

  3. 3. Psychiatric and metabolic disturbances in experimental models of Huntington’s disease

    University dissertation from Department of Experimental Medical Science, Lund Univeristy

    Author : Sofia Hult Lundh; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; huntingtin; Huntington’s disease; hypothalamus; depression; anxiety; metabolism; neuroendocrinology; mouse models; BACHD; rAAV vectors; leptin;

    Abstract : Non-motor symptoms and signs such as metabolic and psychiatric disturbances have been reported to occur early in Huntington’s disease (HD), a fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. However, there is a lack of understanding of the underlying neurobiological mechanisms responsible for the early non-motor features. READ MORE

  4. 4. Hypothalamic and Metabolic Dysfunction in Genetic Models of Huntington’s Disease

    University dissertation from Media-Tryck

    Author : Rana Soylu; Lunds universitet.; Lund University.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hypothalamus; Huntington s disease; metabolism; animal models;

    Abstract : Huntington’s disease (HD) is caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene. HD is an inherited progressive neurodegenerative disorder manifested by the wide array of motor dysfunctions, as well as non-motor symptoms. READ MORE

  5. 5. The Molecular Chaperone DNAJB6 - A Suppressor of Disease Related Amyloid Fibril Formation

    University dissertation from Department of Chemistry, Lund University

    Author : Cecilia Månsson; Lunds universitet.; Lund University.; [2014]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; HSP40; DNAJ; molecular chaperones; amyloid fibrils; Alzheimer’s disease; Huntington’s Disease; crosslinking mass spectrometry; chemical kinetics; aggregation; fibril formation;

    Abstract : Several neurodegenerative diseases are caused by peptides or proteins forming amyloid fibrils such as the Aβ peptide involved in Alzheimer’s disease and the huntingtin exon-1 with a prolonged polyglutamine (polyQ) stretch involved in Huntington’s disease. The ability to form amyloid fibrils is an intrinsic feature in all proteins. READ MORE