Search for dissertations about: "Huntington’s disease"

Showing result 16 - 20 of 47 swedish dissertations containing the words Huntington’s disease.

  2. 16. Development and Applications of in vitro Models to Study Human Brain Evolution and Disease

    Author : Daniela Grassi; Molekylär neurogenetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neural reprogramming; Neural differentiation; Brain development; Huntington s disease; Induced Neuron; Neural Progenitor Cell; Brain evolution;

    Abstract : Neuroscience focusing on human development and disease has long been hampered due to ethical reasons, low tissue availability, and low translatability from animal models. To circumvent these obstacles, we have developed two methods for the investigation of human neural cells in culture. READ MORE

  4. 17. Energy metabolism as a target for new treatment strategies in Huntington’s disease

    Author : Marie Sjögren; Biomarkörer vid hjärnsjukdomar; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Huntington´s disease; Energy metabolic alteration; Weight loss; Skeletal muscle; Adipose tissue; R6 2; Ghrelin; Liraglutide;

    Abstract : Huntington´s disease (HD) is a fatal inherited neurodegenerative disorder caused by a CAG triplet repeat expansion in the huntingtin (HTT) gene and characterized by cognitive and motoric dysfunctions as well as psychiatric problems. Accumulating evidence, however, suggests altered energy metabolism and a hyper-catabolic state as key features of HD pathology. READ MORE

  5. 18. Modern Genes : Body, Rationality and Ambivalence

    Author : Niclas Hagen; Avdelningen för etnologi; []
    Keywords : HUMANIORA; HUMANITIES; Everyday experiences; Modernity; Everyday Life; Lifeworld; System; Genetics; Huntington’s disease.;

    Abstract : The main objective of this ethnological thesis is to investigate the linkage between everyday life with a genetic disease and intrinsic patterns of modernity. The thesis is a compilation thesis that contains four individual articles each addressing the everyday experience of a genetic disease from different angles, with different research questions and theoretical presumptions. READ MORE

  6. 19. Beyond the basal ganglia

    Author : Jorien m van der Burg; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hypothalamus; gastro-intestinal tract; Huntington s disease; metabolism; weight loss;

    Abstract : Huntington’s disease (HD) is a fatal, hereditary disorder caused by a mutation in the gene encoding the protein huntingtin. Although mutant huntingtin is ubiquitously expressed throughout the body, HD research has mainly focused on the role of the basal ganglia. READ MORE

  7. 20. The Regulatory Role of microRNAs in the Mouse and Human Brain

    Author : Rebecca Petri; Molekylär neurogenetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; microRNA; Argonaute; AGO-RIP; let-7; miR-125; adult neurogenesis; olfactory bulb; autophagy; transposable elements; LINE-2; Huntington’s disease;

    Abstract : microRNAs (miRNAs) are 20-24 nucleotides small, single-stranded, non-coding RNAs. They associate with Argonaute (AGO) proteins and exert their function by inhibition or degradation of messenger RNAs. READ MORE