Search for dissertations about: "Hydrogen Deuterium Exchange"

Showing result 6 - 10 of 17 swedish dissertations containing the words Hydrogen Deuterium Exchange.

  2. 6. Advanced computations and mass-spectrometric techniques to unravel the dynamics and interactions of proteins

    Author : Joana Costeira-Paulo; Erik Marklund; Lars Konermann; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; molecular dynamics; mass spectrometry; dihydroorotate dehydrogenase; alpha-synuclein; protein structure; ion mobility; electrospray ionisation; collision cross section; lipids; gas-phase hydrogen deuterium exchange; collision induced unfolding; Biokemi; Biochemistry;

    Abstract : Proteins are an important class of biomolecules, involved in the metabolism, regulation, structure and transport in cells. Unfortunately, many diseases are caused by protein dysfunction. When proteins perform their normal function, they may interact with each other or change their conformation. READ MORE

  4. 7. C–H activation through late transition metal cyclometallation. Addressing selectivity and reactivity problems

    Author : Mikhail Kondrashov; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; C—H activation; cyclometallation; pincer ligands; anion exchange; bimetallic complexes; oxidative functionalisation;

    Abstract : The ligand-directed C—H activation relies on a coordinating donor atom being in proximity to the C—H bond activated. Cyclometallation of 2-(1-naphthyl)-pyridine – a substrate containing both γ- and δ-positions in proximity to the directing nitrogen atom – was studied. READ MORE

  5. 8. Spectroscopic studies of kaolinite surfaces

    Author : Ursula Johansson; Luleå tekniska universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemistry of Interfaces; Gränsytors kemi;

    Abstract : In this thesis, specific surface reactions on kaolinite have been investigated. The methods used are diffuse reflectance Fourier transform (DRIFT), FT-Raman and micro Raman spectroscopy. The deuterium exchange of the hydroxyl protons of kaolinite has been studied. READ MORE

  6. 9. Macromolecules at Interfaces

    Author : Helén Larsericsdotter; Sven Oscarsson; Jos Buijs; Willem Norde; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Protein; Adsorption; Immobilization; Surface; Surface Plasmon Resonance; SPR; Mass Spectrometry; MS; Differential Scanning Calorimetry; DSC; FT ICR; Lysozyme; Bovine Serum Albumin; BSA; Myoglobin; Globular; Kemi; Chemistry; Kemi;

    Abstract : In this thesis, the structure and stability of globular proteins adsorbed onto nanometer-sized hydrophilic silica particles were investigated using differential scanning calorimetry (DSC), hydrogen/deuterium exchange (HDX), and mass spectrometry (MS). The adsorption process itself was characterized with fluorescence and absorption spectroscopy and surface plasmon resonance (SPR). READ MORE

  7. 10. Detection and Structure Elucidation of Drug Metabolites in Biological Samples using HPLC-MS/MS Techniques

    Author : Annica Tevell Åberg; Mikael Hedeland; Ulf Bondesson; Mario Thevis; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry;

    Abstract : This thesis describes the structure elucidation of drug metabolites in biological samples by the use of high performance liquid chromatography (HPLC) atmospheric pressure ionization (API) tandem mass spectrometry (MS/MS). Due to their different advantages, various mass analyzers have been used in the different experiments. READ MORE