Search for dissertations about: "IGF Type 1"

Showing result 1 - 5 of 71 swedish dissertations containing the words IGF Type 1.

  2. 1. Insulin and IGF-I in type 1 diabetes

    Author : Christina Hedman; Claes-Göran Östenson; Linköpings universitet; []
    Keywords : Type I diabetes; IGF-I; IGF system; insulin; insulin analogues; MEDICINE; MEDICIN;

    Abstract : Patients with type I diabetes have alterations in the GH/IGF system with reduced levels of circulating IGF-I, as well as other disturbances in the components of the IGF system.Alterations of both local and circulating IGF-I and its binding proteins (IGFBPs) have been associated with metabolic and vascular manifestations of diabetes and also with atherosclerosis. READ MORE

  4. 2. IGF-I in growth hormone deficiency and in type 1 diabetes

    Author : Bertil Ekman; Jens Sandahl Christiansen; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Both GH-deficiency and type 1 diabetes are associated with low IGF-I levels. The aim with our studies was to develop a dose titration model to obtain physiological IGF-I levels in growth hormone deficiency and to evaluate the relationship between glycaemic control and IGF-I in diabetes. READ MORE

  5. 3. Upper extremity impairments in type 1 diabetes in comparison to matched controls without diabetes : associations to the IGF-system, metabolic factors, disability and quality of life

    Author : Kerstin Gutefeldt; Anna Spångeus; Kerstin Brismar; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Compared with the general population, people with type 1 diabetes (T1D) more often exhibit pathological alterations in musculoskeletal tissue (impairments). Some of these impairments involve the upper extremities, i.e., the shoulders, hands, and fingers. READ MORE

  6. 4. Uncoupling Proteins : Regulation by IGF-1 and Neuroprotection during Hyperglycemia in Vitro

    Author : Helena Gustafsson; Anna Forsby; David Tomlinson; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; uncoupling protein; oxidative stress; diabetes; neuropathy; SH-SY5Y; Neurobiology; Neurobiologi;

    Abstract : Diabetic neuropathy is believed to arise due to oxidative stress following hyperglycemic situations. Uncoupling proteins (UCPs) constitute a subgroup of mitochondrial transporter proteins with putative antioxidant properties. READ MORE

  7. 5. From the pancreatic beta cell to the endothelium:Pathophysiological aspects of Type 2 Diabetes

    Author : Marloes Dekker Nitert; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sekretion; diabetologi; diabetology; insulin secretion; beta cells; glucose tolerance; insulin receptors; IGF-I receptors; endothelial cells; Endokrinologi; Type 2 Diabetes; secreting systems; Endocrinology;

    Abstract : The incidence of Diabetes Mellitus increases globally in epidemic proportions. Type 2 Diabetes is the most prevalent form of Diabetes, comprising 90% of the patients. In Type 2 Diabetes, two processes contribute to the development of the disease: insufficient insulin secretion from the pancreatic ?-cell and insulin resistance of the target organs. READ MORE