Search for dissertations about: "ILK"

Showing result 1 - 5 of 6 swedish dissertations containing the word ILK.

  2. 1. The mechanism of integrin inactivation and cell signalling induced by c-erbB2, an oncogenic growth factor receptor

    Author : Shahram Hedjazifar; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; c-erbB2; integrin á2â1; cell-matrix; integrin conformation; PKB; ERK; Rho; ILK; Nck-2;

    Abstract : Overexpression of the oncogenic growth factor receptor, c-erbB2, is linked with poor prognosis in breast carcinomas and is used as a target for therapeutic strategies. To elucidate the mechanism underlying the tumorigenic action of an elevated c-erbB2 level, leading to homodimerization and activation, we have used an inducible system where a hybrid receptor consisting of the cytoplasmic and transmembrane domains of c-erbB2 fused to the extracellular domain of the trkA NGF receptor has been stably transfected into an immortalized mammary epithelial cell line. READ MORE

  4. 2. Effects of c-erbB2 signaling on morphogenesis and cell adhesion in mammary epithelial cells

    Author : Lachmi E Jenndahl; Göteborgs universitet; []
    Keywords : e-erbB2; integrin alpha2beta1; integrin regulation; ILK; PKB; Rho; epithelial-mesenchymal transition EMT ; E-cadherin; Anchorage independent growth AIG ;

    Abstract : .... READ MORE

  5. 3. Variational methods for phylogeny and single-cell genomics

    Author : Hazal Koptagel; Jens Lagergren; Alexandre Bouchard-Côté; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Variational inference; single-cell DNA sequencing; cell lineage tree; Bayesian phylogenetic tree inference; Variationsinferens; encellig DNA-sekvensering; cellhärkomstträd; Bayesiansk fylogenetisk trädinferens; Varyasyonel çıkarım; tek hücre DNA dizilimi; hücre soy ağacı; Bayesçi filogenetik ağaç çıkarımı; Datalogi; Computer Science;

    Abstract : The investigation of the evolutionary history of organisms, both at the cellular level and at the species level, is a relevant research topic in computational biology. These investigations lead to a deeper understanding of developmental history, cancer progression, the genetic similarity of species, and more. READ MORE

  6. 4. Adhesion Dependent Signals : Cell Survival, Receptor Crosstalk and Mechanostimulation

    Author : Anjum Riaz; Staffan Johansson; Bengt Hallberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Integrins; Signal transduction; Protein kinase B; Akt; PI3K; Heparanase; ROS; Mechanosignalling; Molekylär cellbiologi; Molecular Cellbiology; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi; Cellforskning; Cell Research;

    Abstract : The integrin family of cell surface receptors is evolutionary conserved and found in all multicellular animals. In humans 8-alpha and 18-beta integrins are non-covalently associated into 24 dimers. Integrins mediate cell-extracellular matrix and cell-cell interactions and participate in cell signalling. READ MORE

  7. 5. Integrin Signaling in Cell Adhesion and Mechanotransduction : Regulation of PI3K, AKT, and ROS

    Author : Kathrin Stephanie Zeller; Staffan Johansson; Kristofer Rubin; John Couchman; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; integrin; ROS; PI3K; AKT; mechanosignaling; actin polymerization; spreading;

    Abstract : Integrins are a family of conserved cell surface receptors found throughout the animal kingdom. They comprise 24 dimers in mammals, and regulate a number of processes including cell survival, differentiation, and migration. READ MORE