Search for dissertations about: "INDUCIBLE EXPRESSION"
Showing result 1 - 5 of 269 swedish dissertations containing the words INDUCIBLE EXPRESSION.
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1. Adenovirus vector systems permitting regulated protein expression and their use for in vivo splicing studies
Abstract : We have constructed two adenovirus-based gene expression vector systems permitting regulated protein expression. They are based on the tetracycline-regulated Tet-ON- and the progesterone antagonist RU 486-regulated gene expression systems, which were rescued into E1-deficient adenovirus vectors. READ MORE
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2. Salt-inducible kinases in adipose tissue
Abstract : Obesity, insulin resistance and type 2 diabetes (T2D) are metabolic diseases that increase rapidly in the modern society. The underlying mechanisms are complex and involve both environmental and genetic factors. Adipose tissue is an important organ for maintaining whole body energy homeostasis. READ MORE
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3. Hypoxia inducible factor 1 alpha : dependent and independent regulation of hematopoietic stem cells and leukemia
Abstract : This thesis has studied the role of low oxygen levels, or hypoxia, in hematopoietic stem cells (HSCs) and how, at the molecular level, it regulates stem cell maintenance and protects against oxidative stress induced by reactive oxygen species (ROS). HSCs reside within the bone marrow in specific niches created by a unique vascularized environment, which is suggested to be hypoxic and crucial for HSCs by maintaining a quiescent state of cell cycle and by redirecting metabolism away from the mitochondria to glycolysis. READ MORE
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4. Protein Expression in Baltic Sea Blue Mussels Exposed to Natural and Anthropogenic Stress : The use of stress inducible proteins in ecotoxicological studies
Abstract : The focus of this thesis is the early detection of stress in the environment. It has been proposed that studies on the cellular level would detect stress reactions earlier in time compared to common physiological methods. READ MORE
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5. Defence on Demand : A physiological perspective on phenotypic plasticity in anti-predator traits
Abstract : Almost all species face some degree of predation risk, and, hence, evolution has produced a plethora of anti-predator defences. However, anti-predator strategies require resources, and the prevailing risk of becoming prey is influenced by many factors and rarely constant across time and space. READ MORE