Search for dissertations about: "INVIVO"

Showing result 1 - 5 of 23 swedish dissertations containing the word INVIVO.

  2. 1. Application of Mixed-Effect Modeling to Improve Mechanistic Understanding and Predictability of Oral Absorption

    Author : Martin Bergstrand; Mats O Karlsson; Hans Ericsson; Bart Ploeger; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Absorption; magnetic marker monitoring; drug release; IVIVC; pharmacometrics; NONMEM; model diagnostics; pcVPC; pvcVPC; visual predictive check; VPC; BQL; paracetamol; sulfapyridine.; Other pharmacy; Övrig farmaci; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Abstract : Several sophisticated techniques to study in vivo GI transit and regional absorption of pharmaceuticals are available and increasingly used. Examples of such methods are Magnetic Marker Monitoring (MMM) and local drug administration with remotely operated capsules. READ MORE

  4. 2. Functional Models in the Search for Pharmacological Treatment of Urinary Incontinence : The Role of Adrenergic, Cholinergic, and Serotonergic Receptors

    Author : Ali-Reza Modiri; Karl-Erik Andersson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Neurovetenskap; Neurology; Neurologi; medicinsk farmakologi; Medical Pharmacology;

    Abstract : Stress incontinence and overactive bladder are disorders with a common symptom, urinary incontinence, which is a serious medical and social handicap. Several neurotransmitters regulate the function of the lower urinary tract, including noradrenaline, acetylcholine, and serotonin. READ MORE

  5. 3. Silicone biomaterials obtained by plasma treatment and subsequent surface hydrosilylation

    Author : Björn Olander; KTH; []
    Keywords : Silicone elastomers; PDMS; XPS; ESCA; surface modification; plasma;

    Abstract : The need for safe and functional implants has led to anincreased demand for improved biomaterials. The performance invivo depends on the interaction between the biologicalsurrounding and the surface of the material. READ MORE

  6. 4. Ultrasonic Methods for Quantitative Carotid Plaque Characterization

    Author : Erik Widman; Matilda Larsson; Mark L. Palmeri; KTH; Karolinska Institutet; Karolinska Institutet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Atherosclerosis; Cardiovascular Disease; Carotid Artery; Elasticity; ex vivo; in vivo; Phantom; Plaque; Polyvinyl Alcohol; Pulse Wave Imaging; Shear Wave Elastography; Speckle Tracking; Stroke; Ultrasound; Medical Technology; Medicinsk teknologi; Atherosclerosis;

    Abstract : Cardiovascular diseases are the leading causes of death worldwide and improved diagnostic methods are needed for early intervention and to select the most suitable treatment for patients. Currently, carotid artery plaque vulnerability is typically determined by visually assessing ultrasound B-mode images, which is influenced by user-subjectivity. READ MORE

  7. 5. Experimental Studies of Endocrine Disrupting Compounds in Vascular Cells and Tissues

    Author : Helén Andersson; Eva Brittebo; Malin Celander; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocrine disrupting compounds; endothelium; vascular toxicity; Toxicology; Toxikologi;

    Abstract : Epidemiological evidence suggest that exposure to endocrine disrupting compounds (EDCs) is a risk factor for diseases that involves the cardiovascular system but we know little about the mechanisms whereby these compounds can cause injury in the vasculature. The aim of this thesis was to characterize the effects and mechanisms of some EDCs in vascular cells and highly vascularized tissues. READ MORE