Search for dissertations about: "IgG-binding"
Showing result 1 - 5 of 17 swedish dissertations containing the word IgG-binding.
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1. Evolutionary and functional studies of protein H: a surface molecule of Streptococcus pyogenes
Abstract : Several bacterial species express surface proteins with affinity for the Fc part of human IgG. This thesis describes evolutionary and functional studies of protein H, an IgGFc-binding surface protein of the human pathogen Streptococcus pyogenes. READ MORE
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2. Engineering of small IgG binding domains for antibody labelling and purification
Abstract : In protein engineering, rational design and selection from combinatorial libraries are methods used to develop proteins with new or improved features. A very important protein for the biological sciences is the antibody that is used as a detecting agent in numerous laboratory assays. READ MORE
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3. Site-specific labeling of affinity molecules for in vitro and in vivo studies
Abstract : The thesis is focused on site-specific labeling of affinity molecules for different applications where two types of binding proteins, Affibody molecules and antibodies, have been used. For the purpose of improving the properties of Affibody molecules for in vivo imaging, novel bi-functional chelators for radiolabeling using the radionuclide 111In were evaluated. READ MORE
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4. Molecular analysis of Streptococcus pyogenes and its interactions with the human host
Abstract : Streptococcus pyogenes causes infections only in humans, from trivial tonsillitis to life-threatening conditions. One of its most important virulence factors is the M-like protein family conferring resistance to phagocytosis to the bacterium. The M-like proteins are surface exposed rod-like molecules attached to the cell wall. Each strain of S. READ MORE
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5. Engineering alternative scaffold proteins for conditional targeting
Abstract : Engineering naturally occurring proteins enables us to customize affinity domains according to our specific needs, tailoring them to become an important tool in a wide array of applications limited merely by our creativity. One of nature’s ways to regulate protein activity is by creating a functional change through alteration of a protein’s tertiary structure upon interaction with metal ions. READ MORE