Search for dissertations about: "Immunoglobulin Heavy Chains genetics"

Found 1 swedish dissertation containing the words Immunoglobulin Heavy Chains genetics.

2. 1. Immunoglobulin Gene Analysis in Chronic Lymphocytic Leukemia : Characterization of New Prognostic and Biological Subsets

   Author : Gerard Tobin; Richard Rosenquist; Christer Sundström; Anna Laurell; Nicholas Chiorazzi; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; chronic lymphocytic leukemia; immunoglobulin genes; VH3-21; CDR3; P2X7; Genetik; Clinical genetics; Klinisk genetik;

   Abstract : Recent studies have shown that the somatic mutation status of the immunoglobulin (Ig) VH genes can divide chronic lymphocytic leukemia (CLL) into two prognostic subsets, since cases with mutated VH genes display superior survival compared to unmutated cases. Biased VH gene usage has also been reported in CLL which may reflect antigen selection. READ MORE