Search for dissertations about: "Immunosurveillance"

Showing result 1 - 5 of 15 swedish dissertations containing the word Immunosurveillance.

  2. 1. Potentially Malignant Disorders and Oral cancer -A study on Immunosurveillance

    Author : Jenny Öhman; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oral lichen planus; Leukoplakia; Oral cancer; Immunosurveillance; Solid organ transplantation; T cells; Langerhans cells;

    Abstract : ABSTRACT The cancer immunosurveillance hypothesis postulates that the immune system can recognize cancer cell precursors and destroy those cells before a clinical manifestation occurs. During the last decades several groups have presented evidence of the influence and role of immune activation in oral squamous cell carcinoma (OSCC) patients; however, much less is known about the role of immune activation in potentially malignant oral disorders (PMOD). READ MORE

  4. 2. Exploring the role of mesenchymal stromal cells in endometriosis

    Author : Fawaz Abomaray; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Endometriosis is a chronic inflammatory disease where there is growth of endometrial tissue in ectopic sites, most commonly within the pelvic cavity. The major symptoms of this disease are chronic pelvic pain and infertility. READ MORE

  5. 3. Towards personalized immunotherapy : development of in vitro models for imaging natural killer cell behavior in the tumor microenvironment

    Author : Valentina Carannante; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Tremendous advances in the tumor immunology field have transformed immunotherapy from a promising approach to a standard clinical practice. However, a subset of cancer patients is non-responsive to immunotherapy. More research is therefore needed to understand the mechanisms underlying tumor resistance to immunotherapeutic treatments. READ MORE

  6. 4. T-cell mediated control of Epstein-Barr virus infection : viral mechanisms of immune escape

    Author : Jelena Vladmirovna Levitskaya; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Epstein-Barr virus; Cytotoxic T lymphocyte; CTL epitope; viral immunescape;

    Abstract : Mechanisms regulating the immunogenicity of Epstein-Barr Virus (EBV)-encoded CTL peptide epitopes and their contribution to the escape of virus infected cells from CTL-mediated immunosurveillance were the subject of these studies. It was demonstrated that two HLA A11-restricted CTL epitopes of EBV nuclear antigen (EBNA)-4 (designated IVT and AVF) possessed different immunogenicity that appeared to be due to a rapid surface turnover of All molecules containing the AVF peptide. READ MORE

  7. 5. Fatal attraction : NK cell migration toward and activity in solid tumors

    Author : Veronika Kremer; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Natural killer (NK) cells play a key role in tumor immunosurveillance due to their ability to induce apoptosis of tumor cells and produce pro-inflammatory cytokines, without prior immune sensitization. In particular, NK cells demonstrate potent anti-tumor immune responses against metastases and hematological malignancies. READ MORE