Search for dissertations about: "Initiation codon"

Showing result 1 - 5 of 17 swedish dissertations containing the words Initiation codon.

2. 1. Structural and Genetic Studies of Translation in Escherichia coli

   Author : Qing Zhao; Leif Isaksson; Lars-Göran Öfverstedt; Odd Nygård; Stockholms universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; electron tomography; ribosome; 30S subunit; 50S subunit; rifampicin; Escherichia coli; Translation initiation; Initiation codon; Downstream Region DR ; Microbiology; immunology; infectious diseases; Mikrobiologi; immunologi; infektionssjukdomar;

   Abstract : Ribosomes are the universal ribonucleoprotein organelles that translate the genetic message from mRNA to protein. In prokaryotes, the ribosomal subunits are 30S and 50S subunit, which bind together during the translation process forming 70S ribosome. READ MORE

4. 2. Computational Studies of Protein Synthesis on the Ribosome and Ligand Binding to Riboswitches

   Author : Christoffer Lind; Johan Åqvist; Alexander MacKerell Jr; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Binding free energy; Ribosome; Codon reading; Translation initiation; Translation termination; Mitochondrial translation; Release factor; Purine riboswitch; Molecular Dynamics; Free Energy Perturbation; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

   Abstract : The ribosome is a macromolecular machine that produces proteins in all kingdoms of life. The proteins, in turn, control the biochemical processes within the cell. It is thus of extreme importance that the machine that makes the proteins works with high precision. READ MORE

5. 3. Study on the Function of Translation Initiation Factor IF1

   Author : Victor Croitoru; Leif A. Isaksson; Kim Kusk Mortensen; Stockholms universitet; []
   Keywords : translation; initiation factor IF1; mutagenesis; A-site; RNA chaperone; NATURAL SCIENCES; NATURVETENSKAP;

   Abstract : Initiation is the first step in protein biosynthesis representing a fundamental event in cell life which determines fidelity, efficiency and regulation of gene expression. In addition to the ribosome and mRNA, three protein factors IF1, IF2 and IF3 are involved in the initiation of translation in prokaryotes. READ MORE

6. 4. Studies on Translation Initiation and trans-Translation

   Author : Serhiy Surkov; Leif Isaksson; Udo Bläsi; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; E. coli; ribosome; IF1; tmRNA; trans-translaton; Molecular biology; Molekylärbiologi; molekylärgenetik; Molecular Genetics;

   Abstract :  Translation initiation factor 1 (IF1) is an essential bacterial protein, without any clearly defined function in translation initiation. Same point mutants in this protein exhibit cold-sensitivity. In addition, a sequence specific increase in test protein expression has been observed for these mutants. READ MORE

7. 5. Studies on translation initiation and gene expression in Escherichia coli

   Author : Ernesto I. Gonzalez de Valdivia; Leif Isaksson; Stephen Douthwaite; Stockholms universitet; []
   Keywords : Downstream region; NGG codons; abortive translation; drop-off; Shine-Dalgarno sequence; gene expression and Escherichia coli; NATURAL SCIENCES; NATURVETENSKAP;

   Abstract : In prokaryotes, several mRNA sequences surrounding the initiation codon have been found to influence the translation process; these include the downstream region and its codon context, the Shine-Dalgarno sequence and the S1 ribosomal protein-binding site. In this thesis, the purpose has been to study the role of the downstream region and Shine-Dalgarno-like sequences on early translation elongation and gene expression in Escherichia coli. READ MORE