Search for dissertations about: "Inorganic Pharmaceutical Chemistry"
Showing result 1 - 5 of 23 swedish dissertations containing the words Inorganic Pharmaceutical Chemistry.
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1. Investigating polymorphism in small molecules using three-dimensional electron diffraction
Abstract : For scientific, regulatory and intellectual property reasons, the discovery and characterisation of polymorphic systems is an integral aspect of the development process of any solid-formulated drug product. Yet, these studies are often hindered by crystal quality and size, poor yields and the generation of mixtures of phases. READ MORE
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2. Dissolving the Rocks : Solubility Enhancement of Active Pharmaceutical Ingredients using Mesoporous Silica
Abstract : Poor aqueous solubility is one of the greatest barriers for new drug candidates to enter toxicology studies, let alone clinical trials. This thesis focuses on contributing to solving this problem, evaluating the oral toxicity of mesoporous silica particles, and enhancing the apparent solubility and bioavailability of active pharmaceutical ingredients in vitro and in vivo using mesoporous silica particles. READ MORE
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3. Crystalline Porous Materials Inspired by Metallodrugs
Abstract : Inspiration for developing robust porous materials from sustainable reagents was acquired by determining the crystal structures of bismuth subsalicylate and bibrocathol, two long-used and commonly available bismuth-based pharmaceuticals. From these insights, a number of coordination polymers and metal-organic frameworks (MOFs) were developed, facilitating the synthesis of robust porous materials from sustainably sourced reagents. READ MORE
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4. 3D Electron Diffraction : Application and Development towards High-quality Structure Determination
Abstract : Electron crystallography has been proven to be effective for structure determination of nano- and micron-sized crystals. In the past few years, 3D electron diffraction (3DED) techniques were used for the structure solution of various types of complex structures such as zeolites, metal-organic frameworks (MOF) and pharmaceutical compounds. READ MORE
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5. Selectivity in NMR and LC-MS Metabolomics : The Importance of Sample Preparation and Separation, and how to Measure Selectivity in LC-MS Metabolomics
Abstract : Until now, most metabolomics protocols have been optimized towards high sample throughput and high metabolite coverage, parameters considered to be highly important for identifying influenced biological pathways and to generate as many potential biomarkers as possible. From an analytical point of view this can be troubling, as neither sample throughput nor the number of signals relates to actual quality of the detected signals/metabolites. READ MORE