Search for dissertations about: "Institutionen för genetik och patologi"
Showing result 1 - 5 of 244 swedish dissertations containing the words Institutionen för genetik och patologi.
-
1. Somatic Mutations in Breast Cancer Genomes : Discovery and Validation of Breast Cancer Genes
Abstract : Breast cancer is the most common cancer in women worldwide. However, the genetic alterations that lead to breast cancer are not fully understood. This thesis aims to identify novel genes of potential mechanistic, diagnostic or therapeutic interest in breast cancers by mutational analysis and whole-genome sequencing. READ MORE
-
2. Growth control mechanisms in normal and neoplastic mammalian cells
Abstract : The main theme of the studies presented in this thesis is, the growth control mechanisms whose loss in normal cells predispose to or cause cancer. The balance between growth inhibitory and stimulatory mechanisms is crucial for the development and maintenance of a normal animal. READ MORE
-
3. Molecular biological techniques as a tool in diagnostic pathology : Applications in B-cell lymphoproliferative disease, medullary thyroid carcinoma and cervical carcinoma
Abstract : Identification of malignancy associated with mutations in gene sequences requires detection ofas little as a single base difference. A powerful technique in mutation detection is polymerasechain reaction (PCR) followed by single-strand conformational polymorphism (SSCP) andsequencing. READ MORE
-
4. Studies on Human Endogenous Retroviruses (HERVs) with Special Focus on ERV3
Abstract : Human endogenous retroviruses (HERVs) represent approximately 7% of the human genome. This investigation was focused on one particular HERV, ERV3, with the main purpose of characterising its gene expression patterns and genomic distribution of ERV3-like sequences. READ MORE
-
5. PDGF in cerebellar development and tumorigenesis
Abstract : Medulloblastoma is a highly malignant cerebellar childhood tumor. As in many other brain tumors, expression of platelet-derived growth factor (PDGF) and its receptors has been shown in medulloblastoma. READ MORE