Search for dissertations about: "Integrin transmembrane domain"

Showing result 1 - 5 of 6 swedish dissertations containing the words Integrin transmembrane domain.

2. 1. Mechanisms of Integrin Signal Transduction

   Author : Anne Stefansson; Staffan Johansson; Annika Armulik; Björn Öbrink; Uppsala universitet; []
   Keywords : Cell biology; Integrin; Integrin signalling; PI3K; Akt PKB; Integrin transmembrane domain; cell spreading; Cellbiologi;

   Abstract : Integrins are a protein family of cell surface receptors, expressed in all cell types in the human body, except the red blood cells. Besides their importance in mediating physical connections with the surrounding environment, the integrin family members are also vital signalling mediators. READ MORE

4. 2. Structural and Functional Aspects of β1 Integrin Signalling

   Author : Stina Nilsson; Staffan Johansson; Teet Velling; Maria Fällman; Uppsala universitet; []
   Keywords : Cell and molecular biology; Integrin; Integrin subunit β1; Integrin activation; Threonine; Phosphorylation; Integrin signalling; FAK; PI3K; MAPK; Cell- och molekylärbiologi;

   Abstract : Integrins are transmembrane glycoproteins primarily mediating interactions of cells with the extracellular matrix. Each receptor is a complex of one α- and one β-subunit with affinity for a diverse set of ligands. READ MORE

5. 3. Studies on the transmembrane signaling of β1 integrins

   Author : Annika Armulik; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Integrin β1; signaling; transmembrane domain; CAS; focal adhesion kinase; Biokemi; Biochemistry; Biokemi; Medical Biochemistry; medicinsk biokemi;

   Abstract : Integrins are heterodimeric cell surface receptors, composed of an α and a β subunit, mainly binding for extracellular matrix proteins. lntegrin subunit β1 can combine with at least 12 a subunits and thus form the biggest subfamily within the integrin family. READ MORE

6. 4. The mechanism of integrin inactivation and cell signalling induced by c-erbB2, an oncogenic growth factor receptor

   Author : Shahram Hedjazifar; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; c-erbB2; integrin á2â1; cell-matrix; integrin conformation; PKB; ERK; Rho; ILK; Nck-2;

   Abstract : Overexpression of the oncogenic growth factor receptor, c-erbB2, is linked with poor prognosis in breast carcinomas and is used as a target for therapeutic strategies. To elucidate the mechanism underlying the tumorigenic action of an elevated c-erbB2 level, leading to homodimerization and activation, we have used an inducible system where a hybrid receptor consisting of the cytoplasmic and transmembrane domains of c-erbB2 fused to the extracellular domain of the trkA NGF receptor has been stably transfected into an immortalized mammary epithelial cell line. READ MORE

7. 5. Integrin-interacting proteins in human cancer progression

   Author : Zhengwen An; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Integrins are the major transmembrane receptors for the extracellular matrix (ECM) which regulate a diverse array of cellular functions crucial to tumor cell migration, invasion, proliferation and survival. Integrins contact the ECM via their N-terminal extracellular domains and connect to the intracellular environment via the C-terminal cytoplasmic domains. READ MORE