Search for dissertations about: "Ion exchange chromatography"

Showing result 1 - 5 of 56 swedish dissertations containing the words Ion exchange chromatography.

  2. 1. Tools for digital twins in continuous downstream processing

    Author : Simon Tallvod; Avdelningen för kemiteknik; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Digital twins; Biopharmaceuticals; Downstream processing; Chromatography; Mathematical modeling; Ion exchange; Automation; Sampling; Model calibration; Python;

    Abstract : Biopharmaceuticals are of ever-growing importance for human health. The development and production of biopharmaceuticals has the potential for efficiency improvements by switching from batch-wise to continuous production. READ MORE

  4. 2. Aspects of the Design of Preparative Chromatography for Purification of Antibodies

    Author : David Karlsson; Avdelningen för kemiteknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Kemiteknik och kemisk teknologi; ion-exchange chromatography; adsorption kinetics; gels; model calibration; robustness analysis; optimisation; ESPI; diffusion; steric mass action; Langmuir MPM; antibodies; design; Preparative chromatography; modelling; proteins; Chemical technology and engineering;

    Abstract : The development of biotechnological products is becoming more and more expensive. One type of protein attracting a great deal of attention in the biopharmaceutical industry is antibodies, which was used in this work. READ MORE

  5. 3. Modeling and Calibration of Preparative Chromatography

    Author : Niklas Borg; Avdelningen för kemiteknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Chromatography; Modeling; Simulation; Calibration; Model based analysis;

    Abstract : In my thesis, I have modeled adsorption chromatography and simulated, calibrated, and analyzed models of adsorption chromatography. While my main focus has been modeling and calibration of the models by estimating the parameters, the models used have been partly new. READ MORE

  6. 4. Primary Recovery of Biologically Active Compounds Using Macroporous Monolithic Hydrogels

    Author : Amro Hanora; Bioteknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Downstream processing; macroporous; Biologically active compounds; Biotechnology; Läkemedelsteknik och relaterad teknik; Pharmaceutical and related technologies; Polymerteknik; biopolymers; Biokemisk teknik; Polymer technology; Makromolekylär kemi; Biochemical technology; Affinity chromatography; Ion exchange chromatography; Expanded bed adsorption chromatography.; Macromolecular chemistry; High through put screening; lactica acids; Endotoxin; Plasmid DNA; Cryogel columns; Bioteknik;

    Abstract : The completion of sequencing of human and other mammalian genomes opens a new era for drug development. New approaches have been proposed for tackling diseases such as development of small molecule therapies based on understanding of human genome and proteome, new proteinous based therapies, where the therapeutic protein can inhibit or modify a certain metabolic pathway or DNA-based therapies delivering a gene into the cell (e. READ MORE

  7. 5. Superporous agarose a new material for chromatography

    Author : Per-Erik Gustavsson; Tillämpad biokemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Protein separations; Chromatography; Superporous agarose; Continuous agarose beds; Intraparticle convection; Pore flow; Biochemistry; Metabolism; Biokemi; metabolism; Biotechnology; Bioteknik;

    Abstract : Agarose, the most commonly employed chromatography base material in industrial purification processes for biomolecules – proteins, has almost ideal properties. The major disadvantage of the agarose support is its poor mechanical strength which excludes its use in high speed separations where small particles are needed in order to achieve improved chromatographic efficiency. READ MORE