Search for dissertations about: "Izabela Nita"

Found 1 swedish dissertation containing the words Izabela Nita.

2. 1. Alpha1-Antitrypsin: New insights into the biological role in vitro and in vivo

   Author : Izabela Nita; Enheten för kroniska inflammatoriska och degenerativa sjukdomar; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : Alpha1-Antitrypsin (AAT), an acute-phase glycoprotein produced predominantly in the liver by hepatocytes, but also by macrophages, pulmonary alveolar cells and intestinal epithelial cells, is a member of the SERPIN superfamily (SERine Protease INhibitors), and is one of the major inhibitors of neutrophil elastase in human plasma. Although AAT plays a critical role in regulating inflammation by inhibiting neutrophil serine proteases, recent studies suggest that AAT exhibits much broader anti-inflammatory activity. READ MORE