Search for dissertations about: "Janus kinase"

Showing result 6 - 10 of 13 swedish dissertations containing the words Janus kinase.

  2. 6. Middle ear cholesteatoma : Surgical outcome and aspects of the innate immunity

    Author : Johanna Westerberg; Elina Mäki-Torkko; Henrik Harder; Anna Granath; Juha Silvola; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Cholesteatomas are bone destructive expansions of keratinizing squamous epithelium in the middle ear and temporal bone. Today, surgery is the only treatment. There are several controversies regarding cholesteatomas, including the definition, the pathogenesis and the surgical method. READ MORE

  4. 7. The role of Notch signaling in cancer and metastasis

    Author : Anders P Mutvei; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The Notch signaling pathway is an evolutionary conserved cell-to-cell communication pathway that regulates many important aspects in the development and tissue homeostasis of multicellular animals. It operates in a wide range of cellular contexts and dysregulated Notch signaling has been linked to a number of diseases, including cancer. READ MORE

  5. 8. Growth hormone, JAKs and STATs : a model cytokine signal transduction system

    Author : Tim Wood; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The haematopoietic cytokine family of signalling molecules comprises a variety of polypeptides which have pleiotropic effects on cell differentiation, tissue development and homeostasis. The family includes several interleukins, a variety of growth and colony stimulating factors, erythropoietin, leukaemia inhibitory factor, ciliary neurotrophic factor, the interferons, as well as leptin, prolactin and growth hormone. READ MORE

  6. 9. New neurons and astrocytes in the adult brain. Studies on adult rat neural progenitors in vivo and in vitro with special reference to the effects of IGF-I and CNTF regarding proliferation and lineage determination

    Author : Maria A I Åberg; Göteborgs universitet; []
    Keywords : Brain; hippocampus; rat; neurogenesis; progenitor cell; stem cell; ciliary neurotrophic factor; insulin-like growth factor-I; PI3-K; MAPK.;

    Abstract : The hippocampal dentate gyrus in several species, including man, continues to produce new neurons and glial cells in adulthood. The generation of new neurons and glial cells in the adult hippocampus is under strict regulation. Two major events of significance for cell genesis from progenitor cells are proliferation and lineage determination. READ MORE

  7. 10. Leptin targets in the brain regulating body weight : receptors and down-stream mediators of leptin in neurons of the hypothalamus and brainstem

    Author : Marie-Louise Håkansson Ovesjö; Karolinska Institutet; Karolinska Institutet; []
    Keywords : AGRP; antibody; arcuate nucleus; blood-brain-barrier; body weight; brainstem; CART; CRH; DMX; food intake; GABA; GAD; galanin; hypothalamus; immunohistochemistry; in situ hybridization; lateral hypothalamic area; leptin; leptin receptor; MCH; NPY; obesity; Ob-R; Ob-Rb; oxytocin; paraventricular nucleus; POMC; somatostatin; serotonin; STAT3; supraoptic nucleus; transcription factor; vasopressin; VGAT;

    Abstract : Obesity is a disease which has become a global epidemic that is beginning to replace undernutrition and infectious diseases as the most significant contributor to ill health in the world. In particular, obesity is associated with diabetes mellitus, hypertension and coronary heart disease. READ MORE