Search for dissertations about: "Jonkanal"

Showing result 1 - 5 of 10 swedish dissertations containing the word Jonkanal.

  2. 1. Conformational Changes during Potassium-Channel Gating

    Author : Jakob Renhorn; Fredrik Elinder; David Engblom; Stephan Pless; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ion-channel; electrophysiology; neuron; Jonkanal; neurologi; elektrofysiologi; neuron; aktionspotential;

    Abstract : Voltage-gated ion channels have a paramount importance in many physiological processes such as cell-to-cell communication, action potential-propagation, and cell motility. Voltage-gated ion channels are characterized by their ability to sense membrane voltage and to greatly change channel activity in response to small changes in the voltage. READ MORE

  4. 2. Painfully Energetic : A tale of two proteins potentially connected

    Author : Eva Sperling; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Complex I; Mrp-antiporter; Membrane bound hydrogenases; TRP ion channels; TRPA1; thermosensation; chemosensation; 23Na-NMR;

    Abstract : NADH:quinone oxidoreductase (Complex I) is the first enzyme of the respiratory chain and is involved in energy conservation generating an electro-chemical gradient across a membrane. The enzyme can be divided into a membrane spanning domain and a hydrophilic domain, which protrudes from the membrane. READ MORE

  5. 3. Distribution and function of TRP ion channels in primary sensory neurons

    Author : Helena Sturesson; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurofysiologi; neuropsykologi; histokemi; cytokemi; vävnadskultur; Neurology; neuropsychology; neurophysiology; Neurologi; tissue culture; histochemistry; cytochemistry; Histology; Skin; Immunohistochemistry; Cannabinoid receptor 1 CB1 ; Pain; Primary sensory neurons; TRP ion channels; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi; Histologi;

    Abstract : It is frequently argued that cannabinoids exert part of their analgesic and anti-inflammatory effects via activation of the cannabinoid CB1 receptor located on TRPV1-expressing primary sensory nerve fibres in peripheral tissues. However, we find no evidence of CB1 receptor immunoreactivity on nerve fibres in rat or mouse hindpaw skin and mesenteric artery. READ MORE

  6. 4. Endogenous activators of the pain receptor TRPV1 From cell to man

    Author : Pouya Movahed Rad; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; cannabinoids; capsazepine; N-acylethanolamines; anandamide; blood Circulation; vasodilation; humans; calcitonin Gene-related Peptide; capsaicin; neurogenic inflammation; nociceptors; TRPV1 protein; pain;

    Abstract : N-acylethanolamines (NAEs) belong to a growing family of endogenous signalling molecules acting on a variety of receptors and ion channels. In 1992, it was reported that the N-acylethanolamine anandamide is present in the brain and activates the central cannabinoid (CB) receptor. READ MORE

  7. 5. Mathematical modeling of neurovascular coupling

    Author : Sebastian Sten; Maria Engström; Gunnar Cedersund; Fredrik Elinder; Gaute Einevoll; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The brain is critically dependent on the continuous supply of oxygen and glucose, which is carried and delivered by blood. When a brain region is activated, metabolism of these substrates increases rapidly, but is quickly offset by a substantially higher increase in blood flow to that region, resulting in a brief oversupply of these substrates. READ MORE