Search for dissertations about: "KYNA"
Showing result 1 - 5 of 16 swedish dissertations containing the word KYNA.
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1. Biomarkers of suicide risk in psychosis
Abstract : Suicide and attempted suicide are major health problems. Approximately 1400 people die from suicide every year in Sweden and ten times more attempt suicide. Patients with schizophrenia spectrum psychosis have an increased risk of suicide and suicide rates have been suggested to be as high as 10%. READ MORE
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2. Bridging immune activation with the kynurenine pathway : implications for psychosis
Abstract : Kynurenic acid (KYNA), an endogenous N-Methyl-D-aspartic acid receptor (NMDAR) antagonist, is elevated in patients with schizophrenia. In addition, elevated levels of KYNA are associated with activation of the immune system, which also has been implicated in the development and maintenance of psychotic disorders, including schizophrenia. READ MORE
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3. Influence of kynurenic acid on dopamine neurotransmission : implications for schizophrenia
Abstract : Kynurenic acid (KYNA) belongs to the kynurenines, a group of metabolically related compounds derived from the amino acid tryptophan. It is an antagonist of glutamate- and α7 nicotinic acetylcholine (α7nACh) receptors. Increased levels of KYNA have been observed in the cerebrospinal fluid and postmortem brains of patients with schizophrenia. READ MORE
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4. Imbalanced kynurenine pathway in schizophrenia and depression : immunological and genetic aspects
Abstract : Kynurenic acid (KYNA), an end metabolite of the kynurenine pathway along tryptophan degradation, has gained increasing interest in the pathophysiology of psychiatric disorders. Elevated levels of KYNA have been found in the cerebrospinal fluid (CSF) and in the postmortem brain of patients with schizophrenia and bipolar disorder with psychotic symptoms. READ MORE
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5. Dysregulation of the kynurenine pathway in psychotic disorders : immunological aspects
Abstract : Kynurenic acid (KYNA), a metabolite of the kynurenine pathway, is emerging as a key factor in the development of psychotic disorders. Increased levels of KYNA are found in the brain and cerebrospinal fluid (CSF) of patients with schizophrenia and bipolar disorder, and are associated to psychotic symptoms. READ MORE