Search for dissertations about: "Kirrel"

Found 2 swedish dissertations containing the word Kirrel.

2. 1. Activity-regulated retinoic acid signaling in olfactory sensory neurons

   Author : Hande Login; Staffan Bohm; Mattias Alenius; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mouse olfactory system; RA; neuronal activity; CNG; Cyp26B1; BACE1; Kirrel-2; molekylärbiologi; Molecular Biology;

   Abstract : The aim of the studies included in the thesis is to better understand the interplay between neuronal activity-dependent gene regulation and the bioactive vitamin A metabolite all-trans-retinoic acid (RA) during postnatal development, refinement and maintenance of precise neuronal connectivity using the olfactory sensory neuron (OSN) in the olfactory epithelium (OE) of genetically modified mice as a model. We show that:Inhibition of RA receptor (RAR)-mediated transcription in OSNs reduces expression of the olfactory cyclic nucleotide-gated (CNG) ion channel, which is required for odorant receptor (OR)-mediated stimulus transduction. READ MORE

4. 2. Effects of retinoic acid in the mouse olfactory sensory systems

   Author : Maria Hörnberg; Staffan Bohm; Finn Hallböök; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; olfactory; retinoic acid; neuron survival; Molecular biology; Molekylärbiologi;

   Abstract : A common characteristic in neurodegenerative diseases of the brain is death of specific neuronal populations. The lack of neuron proliferation and axon extension in most parts of the central nervous system leads to chronic loss of neurons in the case of injury or disease. READ MORE