Search for dissertations about: "Kv1.1."

Found 4 swedish dissertations containing the word Kv1.1..

  2. 1. Aspects on the modulation of potassium channels in insulin-producing beta-cells

    Author : Zuheng Ma; Karolinska Institutet; Karolinska Institutet; []
    Keywords : islets of Langerhans; over-stimulation; diazoxide; exocytosis; proteasome; microarray; Kv1.1.;

    Abstract : This thesis attempts to further clarify mechanisms behind the negative effects of overstimulation and the beneficial effect of β-cell rest. For this purpose diazoxide - opener of K+-ATP channels, which reversibly inhibits glucose-induced insulin secretion, was used as a probe. READ MORE

  4. 2. Neural growth : with special emphasis on adult neurogenesis and the effect of antiepileptic drugs

    Author : Malin Almgren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Neurons were for a long time thought to not renew themselves. In the 1960ies the phenomenon of neurogenesis was discovered, but it was not until 1998 that neurogenesis was demonstrated in humans. READ MORE

  5. 3. The megencephaly mouse : from gene to neuronal proliferation

    Author : Ann-Sophie Persson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Megalencephaly; epilepsy; mouse model; genetics; voltage gated potassium channel; hippocampus; proliferation;

    Abstract : Megalencephaly, enlarged brain, can be associated with a wide range of symptoms from benign to severe. Severe cases are often associated with mental retardation and seizures. The megencephaly mouse shows a dramatic, progressive increase in size of the hippocampus and ventral cortex. READ MORE

  6. 4. Role of potassium channels in regulating neuronal activity

    Author : Göran Klement; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Potassium channels; threshold dynamics; trafficking; hERG; SMOCs; excitability;

    Abstract : The firing behaviour of excitable cells is fundamental for the information processing in multicellular organisms, varying from single spikes to different forms of repetitive firing. Of the many regulators, voltage gated potassium channels play a major role. In this thesis some aspects of the potassium channel regulation of firing are explored. READ MORE