Search for dissertations about: "LC MS an UV"

Showing result 1 - 5 of 10 swedish dissertations containing the words LC MS an UV.

2. 1. Introducing weak affinity chromatography to drug discovery with focus on fragment screening

   Author : Minh-Dao Duong-Thi; Sten Ohlson; Brian Dymock; Linnéuniversitetet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; affinity LC-MS; fragment-based drug discovery; fragment screening; high throughput; mass spectrometry; stereoisomer; enantiomer; thrombin; weak affinity chromatography; WAC; WAC-MS.; Biomedical Sciences; Biomedicinsk vetenskap; Biokemi; Biochemistry;

   Abstract : Fragment-based drug discovery is an emerging process that has gained popularity in recent years. The process starts from small molecules called fragments. One major step in fragment-based drug discovery is fragment screening, which is a strategy to screen libraries of small molecules to find hits. READ MORE

4. 2. Development of Methods for the Analysis of Polar Compounds in Environmental Matrices using LC/UV and LC/MS

   Author : Johanna Minten; Margaretha Adolfsson-Erici; Leif Kronberg; Stockholms universitet; []
   Keywords : NATURAL SCIENCES; NATURVETENSKAP; Applied Environmental Science; tillämpad miljövetenskap;

   Abstract : In recent years, the awareness of environmentally hazardous compounds with polar and ionizable properties has intensified. Pharmaceuticals, the pesticide tebuconazole as well as the artificial sweetener sucralose are examples of such new, emerging, contaminants. READ MORE

5. 3. Aspects of Porous Graphitic Carbon as Packing Material in Capillary Liquid Chromatography

   Author : Anna Törnkvist; Wolfgang Lindner; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; PGC; porous graphitic carbon; stationary phase; packing material; LC; liquid chromatography; miniaturized; chiral; enantiomer; ESI; electrospray ionization; mass spectrometry; polar compounds; L-DOPA; dopamine; biological samples; biological matrix; Analytisk kemi; PGC; poröst grafitiserat kol; stationärfas; packningsmaterial; LC; vätskekromatografi; miniatyriserade system; kiral; enantiomer; ESI; electrospray jonisation; mass spektrometri; polära föreningar; L-DOPA; dopmamine; biologiska prover; biologisk matris; Analytical chemistry; Analytisk kemi; Analytical Chemistry; Analytisk kemi;

   Abstract : In this thesis, porous graphitic carbon (PGC) has been used as packing material in packed capillary liquid chromatography. The unique chromatographic properties of PGC has been studied in some detail and applied to different analytical challenges using both electrospray ionization-mass spectrometry (ESI-MS) and ultra violet (UV) absorbance detection. READ MORE

6. 4. Preclinical studies of roscovitine

   Author : Marina Vita; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Roscovitine; Metabolism; Pharmacokinetics; LC-MS; Cdk-inhibitor; Toxicity;

   Abstract : Cyclin-dependent kinases (Cdks) are key enzymes implicated in vital functions of the cell including regulation of the cell cycle, apoptosis, transcription and differentiation. Abnormal regulation of these molecules has been correlated to several diseases, such as cancer, viral infections, neural disorders and kidney inflammations. READ MORE

7. 5. Coupled Liquid Separation and Spectrometric Detection of Organic Compounds Containing Hetero-atoms

   Author : Eva Nilsson; Jean Pettersson; Karin Markides; Joanna Szpunar; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; Analytisk kemi; Analytical chemistry; Analytisk kemi;

   Abstract : This thesis exemplifies the strength in the combination of inductively coupled plasma (ICP) spectrometry and electrospray ionization tandem mass spectrometry ESI-MS/MS as detection techniques for liquid chromatography (LC) in the search for and investigation of compounds that bind or can bind hetero-atoms. Furthermore, some aspects involved in the coupling of LC and ICP spectrometry and quantification without identical standards have been studied. READ MORE