Search for dissertations about: "LUMA"

Showing result 1 - 5 of 8 swedish dissertations containing the word LUMA.

  2. 1. The effect of chronic alcoholism on epigenetic patterns regulating gene expression and neurodegeneration in the human brain

    Author : Sofia Johansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Alcoholism; cognition; drug dependence; brain; frontal cortex; motor cortex; LUMA; epigenetics; methylation; gene expression; endogenous controls; real-time PCR.;

    Abstract : Chronic alcoholism causes about 3.2% of all deaths worldwide. It has an association to about 60 different diseases and injuries with enormous social and economical impact. Despite these facts, very few pharmacological treatments exist and we can still not explain the mechanisms behind addiction, craving and cognitive impairments seen in the abuser. READ MORE

  4. 2. Behind the scenes of thyroid tumors : underlying genetic mechanisms

    Author : Jia Jing Lee; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Familial medullary thyroid cancer; follicular thyroid cancer; anaplastic thyroid cancer; CCND1; UBCH10; p16; RASSF1A; BRAF; array-CGH; tumor progression; global methylation; LINE-1; LUMA;

    Abstract : Thyroid cancer is the most frequently observed malignancy involving endocrine tissues. This group of diseases is also the major cause of death related to neoplasia of the endocrine system. Tumors in the thyroid gland are common in the general population and the majority represents benign follicular adenoma (FTA). READ MORE

  5. 3. Genomic DNA methylation in health and disease

    Author : Mohsen Karimi Arzenani; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cytosine methylation is one of the important epigenetic mechanisms controlling the vertebrate genome. Changes in genomic DNA methylation have been demonstrated in aging, auto-immune diseases and cancer. READ MORE

  6. 4. Mode of delivery, epigenetic modulation and immune cell formation at birth

    Author : Titus Schlinzig; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: Birth by Cesarean section (CS) has been associated with a greater risk for immune disorders like allergy, asthma, type 1 diabetes, celiac disease, inflammatory bowel diseases, and cancer later in life. Although elective CS continues to increase rapidly, it is unclear if and how it may contribute to future health and disease. READ MORE

  7. 5. Local alcohol prevention in Sweden : construction of a prevention index and assessments of prevention effects on consumption and harm

    Author : Tony Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: Over the past 15–20 years, local alcohol and drug prevention has developed substantially in Sweden. This has largely been a planned strategy from the national level with channels through to the regional level and down to the local level, which should be seen as a reaction to Sweden joining the European Union in 1995. READ MORE