Search for dissertations about: "LXR"

Showing result 1 - 5 of 28 swedish dissertations containing the word LXR.

  2. 1. TGFβ and LXR signaling in hepatocellular carcinoma

    Author : Claudia Bellomo; Aristidis Moustakas; Lars Holmgren; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Hepatocellular Carcinoma; high-throughput imaging; small molecules; epithelial plasticity; LXR; Snail; TGFβ; tumor suppression; reactive oxygen species; cancer-associated fibroblast; myofibroblast; Smad3; αSMA;

    Abstract : Hepatocellular carcinoma (HCC) is one of the most prevalent cancer types in the Western world and in the Asia-pacific regions, with its incidence expected to rise up to 22 million cases till 2020. Hepatocellular carcinoma etiology is mainly due to hepatitis B (HBV) and hepatitis C (HCV) infections, and to a lesser extent it is determined by the development of alcohol-driven cirrhosis and non-alcoholic steatohepatitis (NASH). READ MORE

  4. 2. Studies of LXR and CIDEA function in human adipocytes

    Author : Britta Stenson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Obesity, defined as a body mass index of 30 or above, is the result of an imbalance of energy intake and energy expenditure. In the last decade, the obesity prevalence has truly reached epidemic proportions with major effects on public health. READ MORE

  5. 3. LXR regulation of hepatic gene expression and pituitary dependent hormones

    Author : Pia Kotokorpi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Liver X receptor; growth hormone; gene regulation; metabolism; hepatocyte; hepatic steatosis; species differences;

    Abstract : The liver X receptors (LXRs) are ligand activated transcription factors involved in the regulation of metabolic genes. LXRs are considered potential drug targets to treat metabolic disorders, however, unwanted side effects, as revealed from rodent studies, include increased lipogenesis in the liver and increased plasma triglyceride levels. READ MORE

  6. 4. New insights of LXR signalling in inhibition of cancer proliferation and inflammation

    Author : Treska Hassan; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Liver X receptors (LXRs) are ligand-activated transcription factors belonging to the nuclear receptor (NR) superfamily. Up-to-date, more than 1900 publications have established the role of LXRs in cholesterol homeostasis, lipogenesis, glucose metabolism, atherosclerosis, proliferation, and inflammation. READ MORE

  7. 5. LXR and aromatase knock-out mice : animal models providing insight into human diseases

    Author : Hyun-Jin Kim; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In our characterization of mouse strains carrying mutations in nuclear receptor and aromatase genes we have found phenotypes which resemble four human diseases: benign prostatic hyperplasia (BPH), Sjögren s syndrome (SS), amyotrophic lateral sclerosis (ALS), and exocrine pancreatic insufficiency. The work in this thesis was designed to understand the roles of LXRalpha, LXRbeta and aromatase in development of these diseases and to investigate whether these animal models help us (1) to understand the etiology of the corresponding human diseases and (2) to develop new therapeutic approaches for the treatment of these diseases. READ MORE