Search for dissertations about: "LcrH"

Found 5 swedish dissertations containing the word LcrH.

2. 1. Role of YopE and LcrH in effector translocation, HeLa cell cytotoxicity and virulence

   Author : Margareta Aili; Roland Rosqvist; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Yersinia pseudotuberculosis; bacterial pathogenesis; YopE; LcrH; virulence; effector translocation; type III secretion; regulation; Cell and molecular biology; Cell- och molekylärbiologi;

   Abstract : In order to establish an extra-cellular infection the gram-negative bacteria Yersinia pseudotuberculosis uses a type III secretion system (T3SS) to translocate a set of anti-host effectors into eukaryotic cells. The toxins disrupt signalling pathways important for phagocytosis, cytokine production and cell survival. READ MORE

4. 2. Multiple twists in the molecular tales of YopD and LcrH in type III secretion by Yersinia pseudotuberculosis

   Author : Petra J Edqvist; Matthew Francis; Olaf Schneewind; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Yersinia pseudotuberculosis; T3SS; YopD; translocation process; LcrH; class II chaperone; substrate secretion pathway specificity; Molecular biology; Molekylärbiologi;

   Abstract : The type III secretion system (T3SS) is a highly conserved secretion system among Gram negative bacteria that translocates anti-host proteins directly into the infected cells to overcome the host immune system and establish a bacterial infection. Yersinia pseudotuberculosis is one of three pathogenic Yersinia spp. READ MORE

5. 3. Studies of protein structure, dynamics and protein-ligand interactions using NMR spectroscopy

   Author : Tobias Tengel; Göran Larsson; Maria Sunnerhagen; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; 19F NMR; 2S albumin; PapD; protein-ligand interaction; structure; TFE; Yersinia; YopD; allergy; amphipathic helix; Ber e 1; Brazil nut; dynamics; FimC; LcrH; NMR screening; Biophysics; Biofysik;

   Abstract : In the first part of the thesis, protein-ligand interactions were investigated using the chaperone LcrH, from Yersinia as target protein. The structure of a peptide encompassing the amphipathic domain (residue 278-300) of the protein YopD from Yersinia was determined by NMR in 40% TFE. READ MORE

6. 4. Type III secretion- the various functions of the translocon operon in bacterial pathogenesis

   Author : Jeanette E Bröms; Åke Forsberg; Michael Koomey; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Yersinia; Pseudomonas aeruginosa; type III secretion; chaperone; translocation; regulation; lcrGVHyopBD; pcrGVHpopBD; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

   Abstract : In order to establish colonisation of a human host, pathogenic Yersinia use a type III protein secretion system to directly intoxicate host immune cells. Activation of this system requires target cell contact and is a highly regulated process. READ MORE

7. 5. YopD translocator function in Yersinia pseudotuberculosis type III secretion

   Author : Tiago R. D. Costa; Matthew S. Francis; William D. Picking; Umeå universitet; []
   Keywords : Y. pseudotuberculosis; T3SS; translocon; YopD; coiled-coil; effector delivery; regulation; virulence; mikrobiologi; Microbiology;

   Abstract : Type III secretion systems (T3SS) are a common feature of Gram-negative bacteria, allowing them to inject anti-host effectors into the interior of infected eukaryotic cells. By this mechanism, these virulence factors help the bacteria to modulate eukaryotic cell function in its favor and subvert host innate immunity. READ MORE