Search for dissertations about: "Leukotriene"

Showing result 1 - 5 of 107 swedish dissertations containing the word Leukotriene.

  2. 1. Leukotriene C4 synthase : studies on oligomerization and subcellular localization

    Author : Jesper Svartz; Mats Söderström; Sven Hammarström; Colin Funk; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Leukotrienes (LTs) are polyunsaturated fatty acid derivatives formed by oxygenation of arachidonic acid via the 5-lipoxygenase (5-LO) pathway. Upon activation of inflammatory cells 5-LO is translocated to the nuclear envelope where it converts arachidonic acid to the unstable epoxide LTA4. READ MORE

  4. 2. Leukotriene C synthase : an enzyme distinct from microsomal and cytosolic glutathione transferases

    Author : Mats Söderström; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : .... READ MORE

  5. 3. Molecular Pharmacology and Structure Function Modelling of the Leukotriene B4 Receptor BLT1

    Author : Alan Sabirsh; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi; Pharmacological sciences; fluidity; redox; chemotaxis; luciferase; calcium; ligand binding; point mutation; modelling; antibody; BLT1; leukotriene; pharmacology; GPCR; G-protein; receptor;

    Abstract : Leukotrienes are membrane derived bioactive lipids that play an important role in immune responses by initiating and maintaining the inflammatory responses. Leukotriene B4 (LTB4) released at the site of an inflammatory response attracts, activates and prolongs the life of leukocytes and lymphocytes. READ MORE

  6. 4. Signaling and regulation of cysteinyl leukotriene receptors in intestinal epithelial cells and colon cancer

    Author : Astrid Bengtsson; Malmö Cellpatologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TNF alpha; COX-2; interferon alpha; all-trans retinoic acid; EGF; inflammation; colorectal cancer; CysLT2R; Leukotriene; CysLT1R;

    Abstract : Colorectal cancer is the third most common type of cancer, and the second leading cause of cancer-related deaths in the Western world. Chronic inflammation, such as inflammatory bowel diseases (IBD), increases the risk of cancer. Cysteinyl leukotrienes are pro-inflammatory mediators that are involved in IBD. READ MORE

  7. 5. Analysis of epithelial electrophysiological function in paediatric intestinal biopsies

    Author : Annika Reims; Göteborgs universitet; []
    Keywords : Cystic fibrosis; CFTR; coeliac disease; Ussing chamber; intestinal permeability; ion transport; leukotriene; human; duodenum;

    Abstract : Intestinal biopsies are routinely taken from children under investigation of failure to thrive, diarrhoea, abdominal pain and/or malnutrition. These biopsies are usually only evaluated morphologically, i.e. no information is collected with regard to mucosal function. READ MORE