Search for dissertations about: "Lymphopenia Genetics BB Rat Type 1 Diabetes T Cell Receptor Autoimmunity Gimap"

Found 1 swedish dissertation containing the words Lymphopenia Genetics BB Rat Type 1 Diabetes T Cell Receptor Autoimmunity Gimap.

2. 1. Genetic Loci Contributing to Spontaneous Autoimmune Diabetes

   Author : Jessica Fuller; Celiaki och diabetes; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Lymphopenia; BB Rat; Type 1 Diabetes; T Cell Receptor; Autoimmunity; Gimap;

   Abstract : Background and Aims: Spontaneous type 1 diabetes (T1D) in the BioBreeding (BB) rat mimics human T1D as the rats experience weight loss, polydipsia, polyuria, ketoacidosis, onset during puberty and insulin-dependency within a day after diagnosis. Because the DP rat develops T1D spontaneously, it is a prime laboratory animal for dissecting the genetics of T1D susceptibility without the need for external manipulation. READ MORE