Search for dissertations about: "MALDI imaging"

Showing result 1 - 5 of 18 swedish dissertations containing the words MALDI imaging.

  2. 1. Development of MALDI Mass Spectrometry Imaging Methods for Probing Spatial Lipid Biochemistry of Amyloid Plaques in Alzheimer's Disease

    Author : Ibrahim Kaya; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Lipids; Amyloid plaques; Mass spectrometry imaging; MALDI; Trimodal MALDI; Static MALDI; Dual polarity MALDI-MSI on the same pixel points; Neurodegeneration; Immunopathology; Amyloid peptides; APOE; Myelin; Sulfatides; 5xFAD; tgSwe; tgArcSwe; APP;

    Abstract : Alzheimer’s disease (AD) is the most prevalent cause of neurodegenerative dementia. Aggregation of amyloid β (Aβ) peptides into extracellular Aβ plaques is one of the major neuropathological features of AD. READ MORE

  4. 2. Development and Application of Software Tools for Mass Spectrometry Imaging

    Author : Patrik Källback; Per E. Andrén; Per Svenningsson; Anna Nilsson; Benjamin Bowen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mass spectrometry imaging; MALDI; DESI; msIQuant; quantitation; neurotransmitters; drugs; derivatization; brain; compression; data entropy reduction;

    Abstract : Mass spectrometry imaging (MSI) has been extensively used to produce qualitative maps of distributions of proteins, peptides, lipids, neurotransmitters, small molecule pharmaceuticals and their metabolites directly in biological tissue sections. Moreover, during the last 10 years, there has been growing demand to quantify target compounds in tissue sections of various organs. READ MORE

  5. 3. Spatial analysis of lipids in tissue samples applying mass spectrometry imaging

    Author : Masoumeh Dowlatshahi Pour; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; SIMS; MALDI; Mass spectrometry imaging; Lipid; ME-SIMS; Sample preparation;

    Abstract : Lipids are important naturally occurring components in all living cellular organisms. They serve as the main building blocks of cellular membranes, participate in many signaling pathways and are also stored as an energy source. READ MORE

  6. 4. Detection of Lipids and Proteins on Biological Surfaces using Imaging Mass Spectrometry

    Author : Louise M Carlred; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ToF-SIMS; GM1; cholesterol; Amyloid-β; phospholipids; Imaging Mass Spectrometry; Alzheimer’s disease; sulfatides; QCM-D; MALDI;

    Abstract : Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is a technique that can be used for imaging the spatial distribution of many different molecules at the same time. It is very sensitive for detection of small biomolecules, such as lipids, whereas larger biomolecules, such as peptides and proteins, cannot be detected as intact entities due to fragmentation. READ MORE

  7. 5. Imaging neurochemical changes associated with Parkinson´s disease and L-DOPA-induced dyskinesia using mass spectrometry

    Author : Elva Fridjonsdottir; Per E. Andrén; Miles Trupp; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mass spectrometry imaging; MALDI; Parkinson´s disease; L-DOPA-induced dyskinesia;

    Abstract : Parkinson’s disease (PD), caused by a loss of midbrain dopamine neurons, is the second most common neurodegenerative disease worldwide after Alzheimer’s disease. The primary treatment choice for PD is L-DOPA, the precursor for dopamine, which only affects symptoms and does not inhibit disease progression. READ MORE