Search for dissertations about: "MASH1"

Showing result 1 - 5 of 8 swedish dissertations containing the word MASH1.

  2. 1. Gene therapy of neuroblastoma

    Author : Yvonne Arvidsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuroblastoma; gene therapy; PNP; ASK1; MASH1; IL-12; GM-CSF; immunotherapy; apoptosis.;

    Abstract : Aims: The survival of children with advanced stages of neuroblastoma has not improved significantly during recent years. Therefore additional treatments based on other modalities need to be developed. The objective of this thesis was to investigate the possibility to develop gene therapy of neuroblastoma. READ MORE

  4. 2. On molecular mechanisms of neural differentiation and forebrain development

    Author : Erik Södersten; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Telencephalic development is an extraordinary complex process where neural structures of highly diverse cell compositions emerge as the result of multiple developmental strategies imposing tight regulation, balance and timing of gene expression. Embryonic telencephalic neural stem cells (NSCs) can form the major cell types found in the telencephalon, and are thus an excellent model for studying transcriptional control of lineage choice mechanisms in CNS development. READ MORE

  5. 3. Survival and differentiation of central noradrenergic neurons

    Author : Pontus Holm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : About half of all central noradrenergic (NA) neurons reside in the locus coeruleus (LC). Projections from the LC reach target regions throughout the entire brain and regulate a variety of functions, such as mood, vigilance, arousal, sleep, attention and memory acquisition. READ MORE

  6. 4. Molecular mechanisms for lineage-restricted differentiation of adult neural progenitors

    Author : Muna Elmi; Göteborgs universitet; []
    Keywords : ;

    Abstract : Aims: In the central nervous system of several species, including humans, neurogenesis per?sists even in the adult life in discrete neurogenic regions of the brain. Adult neural stem cells derived from these neurogenic areas are proliferating cells, which can differentiate to neurons, astrocytes, and oligodendrocytes. READ MORE

  7. 5. Regulation of midbrain dopaminergic neuron development by Wnts, sFRPs and bHLH proteins

    Author : Julianna M V Kele-Olovsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Parkinson’s disease (PD) is a chronic neurodegenerative disorder. The main pathology is characterized by progressive degeneration of the dopaminergic (DA) neurons of the substantia nigra leading to loss of striatal dopamine innervation. The knowledge about the fundamental mechanisms behind the degenerative process has been limited. READ MORE