Search for dissertations about: "MASS-SPECTROMETRY"
Showing result 1 - 5 of 1119 swedish dissertations containing the word MASS-SPECTROMETRY.
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1. Improved Neuropeptide Identification : Bioinformatics and Mass Spectrometry
Abstract : Bioinformatic methods were developed for improved identification of endogenous peptides using mass spectrometry. As a framework for these methods, a database for endogenous peptides, SwePep, was created. It was designed for storing information about endogenous peptides including tandem mass spectra. READ MORE
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2. Mass Spectrometry-based Neuroproteomics : Deciphering the Human Brain Proteome
Abstract : Mammalian brain is challenging to study due to its heterogeneity and complexity. However, recent advances in molecular imaging, genomics and proteomics have contributed significantly to achieve insights into molecular basis of brain function and pathogenesis of neurological disorders. READ MORE
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3. Liquid Chromatography Coupled to Mass Spectrometry : Implementation of Chemometric Optimization and Selected Applications
Abstract : Liquid chromatography (LC) coupled to mass spectrometry (MS) offers highly selective and sensitive analysis of a wide variety of compounds. However, the use of hyphenated experimental set-ups implies that many parameters may have an effect on the studied response. READ MORE
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4. Novel strategies to increase throughput and differentiate lipid isomers in mass spectrometry imaging : Development of computational tools and complex mass spectrometric methods for nanospray desorption electrospray ionization
Abstract : In this thesis, method development for improved analyte identification and throughput in mass spectrometry imaging (MSI) is discussed. In MSI, the spatial distribution of analytes from a sample is determined and visualized, information about the detected molecules interaction within the sample can thereby the deduced. READ MORE
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5. Analytical developments and applications of ambient mass spectrometry imaging : Visualizing challenging analytes and understanding chemical mechanisms of ischemic stroke
Abstract : Bioanalytical methods that provide spatial information on molecular distributions are important for deep understanding of chemical mechanisms in health and disease. For instance, the localized action of drugs and metabolites can provide valuable information on metabolism in specific cellular regions, which would not be possible with bulk analysis. READ MORE