Search for dissertations about: "MEK1"
Showing result 1 - 5 of 21 swedish dissertations containing the word MEK1.
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1. Design and Synthesis of Chalcone and Chromone Derivatives as Novel Anticancer Agents
Abstract : This thesis comprises the design and synthesis of chalcone and chromone derivatives and their use in various biological applications, particularly as anticancer agents (targeting proteins associated with cancer pathogenesis) and as potential fluorophores for live-cell imaging. Conveniently, all structures presented were synthesized from commercially available 2 ́-hydroxyacetophenones. READ MORE
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2. Macrophage Activation and AP-1 in Atherosclerosis
Abstract : High levels of very low density lipoprotein (VLDL) and intermediate density lipoprotein (IDL) have been identified as independent risk factors for coronary heart disease. Hypertriglyceridemia is generally associated with an increased expression of inflammatory makers and inflammation is thought to contribute to atherosclerosis and its complications. READ MORE
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3. Exercise effects on the mitogen-activated protein (MAP) kinase cascade in skeletal muscle
Abstract : Exercise-induced adaptations in skeletal muscle are regulated by numerous signaling mechanisms. However, little is known about the molecular signaling mechanisms linking muscle contraction or other exercise-associated stimuli to intracellular responses in skeletal muscle. READ MORE
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4. Stroke, Sex and Vascular Receptor Changes in the Brain
Abstract : Stroke is a severe cerebrovascular disease in which the neuronal tissue and vasculature of the brain undergo ischemia-evoked alterations. We have demonstrated an increased expression of cerebrovascular contractile receptors in the brain. This is hypothesized to mitigate cerebral blood flow and exacerbate tissue damage after stroke. READ MORE
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5. Gene regulation, intracellular signaling and membrane traffic : studies in primary human skeletal muscle cultures
Abstract : Skeletal muscle is an insulin sensitive organ and plays a major role in whole body electrolyte and substrate homeostasis in the post prandial state. Impaired insulin action in skeletal muscle may lead to the pathological condition of insulin resistance. READ MORE