Search for dissertations about: "MHC class I tetramers"
Found 4 swedish dissertations containing the words MHC class I tetramers.
-
1. NK cell inhibitory receptor interactions with MHC class I molecules
Abstract : Natural killer (NK) cells represent the third population of lymphocytes in size after B- and T-cells. NK mediated killing of target cells is strongly influenced by MHC class I molecules expressed on target cells. In contrast to T-cells, NK cells can be inhibited by MHC class I molecules through the action of specific inhibitory NK cell receptors. READ MORE
-
2. Structural studies of MHC class 1 complexes : implications for NK- and T-cell recognition
Abstract : The cell-cell recognition events and the functional characteristics of the cell surface receptors that govern the responses of NK- and T-cells are central to molecular immunology. This thesis addresses the structural basis of such molecular recognition, more specifically the interaction between peptides and MHC class I molecules, as well as the interaction between such complexes and the inhibitory Ly49 receptors of NK cells or triggering antigen specific receptors of T-cells (TCR). READ MORE
-
3. Decoding NK cell receptor specificity : functional and structural studies of MHC class 1 subcomponents
Abstract : Natural Killer (NK) cells are an important part of the innate immune system. They can lyse target cells and secrete immunoregulatory cytokines early during immune responses. They mediate protection against viruses and tumours, and can reject MHC class I mismatched bone marrow grafts. READ MORE
-
4. Regulation of non-responsiveness and death in cytotoxic T cells by the agonistic potency of MHC : peptide ligands
Abstract : CD8+ T lymphocytes are important for immunological control of infections and tumors. The key interaction required to initiate the process of T cell activation is the engagement of the T cell receptor (TCR) with a major histocompatibility complex (MHC) class I/peptide complex on an antigen presenting cell (APC). READ MORE
