Search for dissertations about: "MHC class in tumor"

Showing result 1 - 5 of 56 swedish dissertations containing the words MHC class in tumor.

  2. 1. Lymphoid development and function in MHC class I deficient mice

    Author : Sofia Freland; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MHC class I; T cell selection; cytotoxic T lymphocyte; antigen presentation; MHC class I deficient mice; NK cell; tumor growth;

    Abstract : MHC class I molecules present short peptide fragments, derived from proteins synthesized in the cytosol, to specific CTL. The MHC class I molecule is a heterotrimer encompassed of a polymorphic transmembrane glycoprotein (heavy chain), ß2-microglobulin (ß2m), and a peptide. READ MORE

  4. 2. Immunity and immunosuppression in the tumor-host interaction

    Author : Max Petersson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Tumors; MHC class 1; natural processed peptides; T cells; NK cells; IFN-[gamma]; IL-10; TAP;

    Abstract : With the advent of new methods in molecular biology and in peptide isolation, a number of tumor-associated antigens and their epitopes have been identified and characterized. However, tumors often grow progressively evolving different mechanisms of immune escape, resulting in resistance to MHC class I-restricted tumor-specific T cells. READ MORE

  5. 3. Natural killer cell tolerance : influence of the MHC class I expression in the host

    Author : Maria H Johansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : NK cells; MHC class 1; tolerance; transgenic mice; Ly49;

    Abstract : Development of self-tolerance in the immune system is characterized by somatic processes aiming at permanently eliminating, or silencing, potentially autoreactive lymphocytes. Such tolerance mechanisms are of outmost importance if autoimmunity is to be avoided. READ MORE

  6. 4. Mapping of the specificity in MHC class I recognition by natural killer cells

    Author : Margareta Waldenström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Natural killer (NK) cells represent the third major lymphocyte subpopulation. They are distinguishable from B and T lymphocytes by their surface phenotype, cytokine profile and the ability to mediate spontaneous cytotoxicity, without prior sensitization, against certain tumor cells and virally infected cells. READ MORE

  7. 5. Studies of cytotoxic T lymphocytes and natural killer cells in relation to MHC class I presented peptides

    Author : Lars Franksson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : T-cell; NK cell; MHC class I; peptide;

    Abstract : In the defense against disease it is essential for the immune system to be able to discriminate self/normal from non-self/abnormal. This key feature of the immune system relies on the presentation of antigens by MHC class I and class II molecules. READ MORE