Search for dissertations about: "MHC-I"
Showing result 1 - 5 of 28 swedish dissertations containing the word MHC-I.
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1. The MHC genes: variation and impact on life-history traits in house sparrwos
Abstract : In birds the major histocompatibility complex (MHC) organization differs both among and within orders. Galliformes often have simple arrangements with few transcribed MHC genes whilst many songbirds (Passeriformes) have a complex arrangement with many MHC genes and also presence of pseudo-genes. READ MORE
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2. Avian MHC : Characterization and expression patterns of classical and non-classical MHC-I genes
Abstract : The function of the vertebrate immune system is to enable recognition and elimination of microorganisms that can cause harm (pathogens). A key component in adaptive immunity is the major histocompatibility complex (MHC) that codes for molecules with antigen presentation function. READ MORE
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3. Natural killer cell education under conditions of perturbed sensing of MHC : studies in MHC-I mosaic and chimaeric mice
Abstract : Natural killer (NK) cells are innate lymphocytes that play a role in infections, tumours and transplantation. Their activating and inhibitory receptors sense cell surface ligands on potential target cells. READ MORE
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4. MHC diversity and expression in a songbird : Temporal and transgenerational variation
Abstract : The immune system is of central importance to clear-off pathogens in order to keep an organism healthy. In vertebrates, the Major Histocompatibility Complex (MHC) is a genomic region that holds key genes involved in adaptive immunity and in particular in the antigen presenting process. READ MORE
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5. Processing and presentation of exogenous antigen by dendritic cells
Abstract : Dendritic cells (DC) play a key role in the immune system. In this thesis, we have investigated and characterized pathways for the processing and presentation of exogenous OVA on MHC-I ("cross-presentation") and how these were influenced by the purine nucleoside Adenosine (Ado), an immune regulator that accumulates to high concentrations at sites of inflammation and tumor growth. READ MORE