Search for dissertations about: "MIPI"

Found 4 swedish dissertations containing the word MIPI.

  2. 1. Mantle cell lymphoma strategies in primary treatment

    Author : Alexandra Albertsson Lindblad; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mantle cell lymphoma; registry data; Clinical Trial; Phase I; Clinical Trial; Phase II; rituximab; bendamustine; lenalidomid; ibrutinib; ADCC; in vitro model; TP53 mutations; watchful waiting; mantle cell lymphoma; real-world data; lenalidomide; rituximab; bendamustin; ibrutinib; ADCC; TP53 mutation; CDKN2A; NGS; MIPI; Watchful waiting;

    Abstract : Mantle cell lymphoma (MCL) is associated with poor prognosis due to an aggressive clinical course. Being a rare disease, there are few randomized trials in MCL and there is no defined golden standard in primary treatment. READ MORE

  4. 2. SOX11 in Mantle Cell Lymphoma - Novel Tools for Diagnostic, Prognostic and Functional Investigations

    Author : Lena Nordström; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibodies; DNA methylation; Epigenetics; SOX11; Lymphoma;

    Abstract : The goal of biomarker discovery is to identify disease defining molecules, which could be used to improve early detection and/or to predict survival and response to treatment. This thesis is about the transcription factor SOX11, a protein discovered in the context of mantle cell lymphoma in 2008, which shows great potential to be used as a clinical relevant biomarker. READ MORE

  5. 3. Functional studies of SOX11 and T-STAR - Translation of tumor-associated genes into clinical and biological insight

    Author : Sandra Sernbo; Institutionen för immunteknologi; []
    Keywords : ;

    Abstract : Cancer is a disease that will affect most of us during a lifetime. Although the survival of cancer patients has incresed due to better treatment and earlier diagnosis, the prevalance of the disease is still increasing. This increase in the number of cancer cases diagnosed will impose a challenge to the cancer care and higher costs for socitey. READ MORE

  6. 4. The immune microenvironment in mantle cell lymphoma : Targeted liquid and spatial proteomic analyses

    Author : Lavanya Lokhande; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mantle cell lymphoma MCL ; proteomic analyses; spatial analysis; Biomarker discovery; immune microenviroment; serum proteomics;

    Abstract : The complex interplay of the tumour and immune cells affects tumour growth, progression, and response to treatment. Restorationof effective immune response forms the basis of onco-immunology, which further enabled the development of immunotherapy. READ MORE