Search for dissertations about: "MITOCHONDRIAL-DNA DELETIONS"

Showing result 1 - 5 of 6 swedish dissertations containing the words MITOCHONDRIAL-DNA DELETIONS.

  2. 1. Molecular insights into mitochondrial DNA replication

    Author : Javier Miralles Fusté; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mitochondria are organelles found in eukaryotic cells. These organelles produce most of the adenosine triphosphate that cells use as a source of energy. Mitochondria contain their own genomic material, a circular DNA genome (mtDNA) that encodes subunits of the respiratory chain complexes and RNA components needed for mitochondrial translation. READ MORE

  4. 2. lnclusion body myositis - Genetic, clinical, and epidemiological aspects

    Author : Ulrika Lindgren; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; inclusion body myositis; mitochondrial DNA; epidemiology; cytochrome c oxidase; inflammatory myopathy;

    Abstract : The inflammatory myopathy inclusion body myositis (IBM) is characterized by progressive muscle weakness and dysphagia in individuals over 45 years of age. Muscle biopsy shows inflammatory infiltrates, vacuoles with protein accumulation and cytochrome c oxidase (COX)-deficient muscle fibers. READ MORE

  5. 3. Crisis in Energy Metabolism - Mitochondrial Defects and a New Disease Entity

    Author : Gittan Kollberg; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Energy metabolism; Mitochondrial Disorders; mtDNA; multiple mtDNA deletions; Alpers-Huttenlocher syndrome; POLG1; GYS1; glycogen synthase; point mutation; Polymerase gamma;

    Abstract : Impairment of energy metabolism may be associated with severe implications for affected individuals since all fundamental cell functions are energy-dependent. Disorders of energy metabolism are often genetic and associated with defects in the oxidative phosphorylation in mitochondria. READ MORE

  6. 4. Functional and structural characterization of the human mitochondrial helicase

    Author : Jenny Korhonen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Mitochondria; mtDNA; replication; replisome; TWINKLE; mtSSB; POL g ; adPEO.;

    Abstract : Mitochondria are the energy producing organelles of the eukaryotic cell. The human mitochondrial DNA (mtDNA) is a double stranded circular molecule of about 16 kb, usually present at 1000-10 000 copies per cell. The genome encodes 13 polypeptides involved in respiration, two ribosomal RNA s and a set of 22 transfer RNA s. READ MORE

  7. 5. The Genetics of Adaptation and Evolvability in Yeast

    Author : Karl Persson; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Evolution; Genetics; Adaptation; Evolvability; Yeast;

    Abstract : Evolution is the hereditary change in life forms that has shaped the divergence of all organisms that inhabit planet Earth. I used the yeast Saccharomyces cerevisiae to study how adaptive evolution increases the fitness and changes the properties of experimental and natural yeast populations. READ MORE