Search for dissertations about: "MT2"

Showing result 1 - 5 of 6 swedish dissertations containing the word MT2.

  2. 1. Melatonin receptors in pancreatic islets - Linking a genetic variant to functional phenotype

    Author : Cecilia Nagorny; Diabetes - molekylär metabolism; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melatonin receptor; knock out mice; IVGTT; OGTT; ITT; Hyperinsulinemic clamp; MTNR1B; MT2;

    Abstract : Defective insulin secretion and insulin resistance are the two hallmarks of Type 2 Diabetes (T2D). The pathophysiology of the disease is not fully understood but genetic susceptibility for the disease is a new major player in the understanding of the underlying mechanisms. READ MORE

  4. 2. Melatonin in the gastrointestinal tract

    Author : Fanny Söderquist; Janet Cunningham; Annica Jacobson; Bodil Ohlsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; melatonin; MT1; MT2; gastointestinal tract; small intestinal neuroendocrine tumours; IBS; depression; anxiety; personality and affective disorder; Medicinsk vetenskap; Medical Science; Psychiatry; Psykiatri;

    Abstract : Melatonin is recognised as the pineal hormone regulating sleep and circadian rhythm. It has also been identified in peripheral tissues (mainly in animals) and thought to display a variety of actions, including anti-inflammatory properties, regulation of gastrointestinal (GI) functions, glucose homeostasis and beneficial effects in different tumour types. READ MORE

  5. 3. Melatonin and its receptors in the normal human gastrointestinal tract, pancreas and in small intestinal neuroendocrine tumours

    Author : Fanny Söderquist; Janet Cunningham; Lisa Ekselius; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Melatonin, “the hormone of darkness” is well known to regulate sleep and circadian rhythm. However, melatonin is also present in numerous peripheral tissues and the number of actions assigned to this neurohormone is growing steadily. READ MORE

  6. 4. Secretory and anti-inflammatory actions of some gastro-intestinal hormones in salivary glands

    Author : Hülya Çevik Aras; Göteborgs universitet; []
    Keywords : salivary glands; protein secretion; synthesis; inflammation; β-defensins; myeloperoxidase; cholecystokinin; gastrin; melatonin; nitric oxide; nerve stimulation;

    Abstract : Textbooks generally state that the secretory activity of salivary glands is solely regulated by nerves. This view is challenged in the present Thesis, using the parotid gland of the anaesthetized rat as experimental in vivo model. READ MORE

  7. 5. Matrix metalloproteinases in natural killer cells. Expression of MMPs, IL-2 activation and killer cell interactions with Matrigel® and model tumours

    Author : Per Albertsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Protease; matrix metalloproteinase; killer cell; IL-2; Matrigel; B16 melanoma; tumour infiltration; invasion assay; zymography; Western blot; RT-PCR; light microscopy; fluorescence; electron microscopy;

    Abstract : Introduction: IL-2 activated natural killer (A-NK) cells can recognize malignant cells and exert tumouricidal activities by multiple mechanisms that require close contact with the target cells. Upon adoptive transfer, some A-NK cells accumulate in tumours by migrating from the vascular bed to a position inside the malignant tissue, forming close contacts with target cells. READ MORE