Search for dissertations about: "MUC1"

Showing result 1 - 5 of 16 swedish dissertations containing the word MUC1.

  2. 1. Antigens derived from the mucin MUC1 : Solution and solid-phase synthesis of saccharides, peptides and glycopeptides

    Author : Maciej Pudelko; Mikael Elofsson; Fredrik Almqvist; Thisbe K. Lindhorst; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Lactones; glycopeptides; signal peptide; neoglycolipid arrays; solid-phase synthesis; MUC1; gel-phase 19F NMR spectroscopy; fluorinated alpha-amino protective group; Organic chemistry; Organisk kemi;

    Abstract : Mucin is a term used to describe a large family of heavily glycosylated proteins which are present on the surfaces of secretory epithelial cells and are overexpressed by many carcinomas. Membrane-bound mucin MUC1 is of special interest. Its backbone consists of repeating units of twenty amino acids with five potential glycosylation sites. READ MORE

  4. 2. Mucins, Cystic Fibrosis and PDZ protein interactions

    Author : Emily Malmberg; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mucin; PDZ; transmembrane; MUC1; Cystic Fibrosis; clathrin; CFTR; PDZK1; Bcr; endocytosis; MUC17;

    Abstract : Cystic Fibrosis (CF) is caused and characterized by mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene. The dominating feature of the disease is mucus accumulation on mucosal surfaces, but no direct functional connection between mucus and CFTR is known. READ MORE

  5. 3. Autoproteolysis accelerated by conformational strain - a novel biochemical mechanism

    Author : Denny Johansson; Göteborgs universitet; []
    Keywords : SEA domain; autoproteolysis; MUC1; conformational strain; protein folding;

    Abstract : Natural fragmentation of polypeptide chains by autoproteolysis occurs in a number of protein families. It is a vital step in the maturation of several enzymes and in the formation of membrane-associated mucins that constitute a part of the protective mucus barrier lining epithelial cells. READ MORE

  6. 4. Alterations of mucin O-glycosylation in response to intestinal infection. Importance of specific glycosyltransferases

    Author : Fredrik J. Olson; Göteborgs universitet; []
    Keywords : mucins; altered O-glycosylation; Nippostrongylus brasiliensis infection; blood group A glycosyltransferase; Muc2; MUC1; GalNAc-T4; mass spectrometry;

    Abstract : Mucins are large glycoproteins constituting the major protein component of the mucus layer covering the epithelial surfaces. The mucins are characterised by a dense and heterogeneous O-glycosylation, important for their chemical and physiological properties. READ MORE

  7. 5. Functional genetic studies of Psoriasin: a potential biomarker for breast cancer with a poor prognosis

    Author : Stina Petersson; Göteborgs universitet; []
    Keywords : Psoriasin; Breast cancer; Reactive oxidant species; NF-κB; IFNγ; STAT1; ICAM-1; MUC1; CD24;

    Abstract : Breast cancer is the most common malignancy in women. There is a high degree of heterogeneity in breast tumours and they can be divided into subtypes that have different expression pattern and clinical outcome. Ductal Carcinoma in situ (DCIS) is regarded as a precursor of invasive ductal breast cancer. READ MORE