Search for dissertations about: "Mechanism-based"

Showing result 1 - 5 of 55 swedish dissertations containing the word Mechanism-based.

2. 1. Mechanism-Based Pharmacokinetic and Pharmacodynamic Modelling of Paclitaxel

   Author : Anja Henningsson; Mats O. Karlsson; Lena Friberg; Iñaki F. Trocóniz; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Pharmacodynamics; Mechanism-based; Modelling; Myelosuppression; Paclitaxel; Cremophor EL; NONMEM; Farmakokinetik Farmakoterapi; PHARMACY; FARMACI;

   Abstract : Paclitaxel (Taxol®) is now widely used against breast, ovarian and non-small-cell lung cancer. Anticancer agents generally have narrow therapeutic indices, often with myelosuppression (mainly neutropenia) as dose-limiting side effect. READ MORE

4. 2. Mechanism-Based Modeling of the Glucose-Insulin Regulation during Clinical Provocation Experiments

   Author : Petra Jauslin-Stetina; Mats Karlsson; Nicolas Frey; Philippe Jacqmin; Uppsala universitet; []
   Keywords : Pharmacokinetics Pharmacotherapy; Glucose homeostasis; Type 2 diabetes; IVGTT; OGTT; Meal test; Circadian variation; Mechanism-based; NONMEM; Farmakokinetik Farmakoterapi;

   Abstract : Type 2 diabetes is a complex chronic metabolic disorder characterized by hyperglycemia associated with a relative deficiency of insulin secretion and a reduced response of target tissues to insulin. Considerable efforts have been put into the development of models describing the glucose-insulin system. READ MORE

5. 3. Mechanism-based flow stress model for Ti-6Al-4V : applicable for simulation of additive manufacturing and machining

   Author : Bijish Babu; Lars-Erik Lindgren; Jean-Philippe Ponthot; Luleå tekniska universitet; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Material modeling; Ti-6Al-4V; dislocation density; vacancy concentration; additive manufacturing; hot forming; heat treatment; Material Mechanics; Materialmekanik;

   Abstract : Ti-6Al-4V has remarkable properties such as high specific mechanical properties (viz. stiffness, strength, toughness, fatigue resistance), corrosion resistance, biocompatibility etc. These properties make it attractive for applications in aerospace, chemical industry, energy production, surgical implants, etc. READ MORE

6. 4. Safety and Efficacy Modelling in Anti-Diabetic Drug Development

   Author : Bengt Hamrén; Mats O Karlsson; Eric Snoeck; Uppsala universitet; []
   Keywords : Pharmaceutical biosciences; pharmacokinetic; pharmacodynamic; mechanism-based; modelling; type 2 diabetes mellitus; tesaglitazar; PPAR; drug development; NONMEM; Farmaceutisk biovetenskap;

   Abstract : A central aim in drug development is to ensure that the new drug is efficacious and safe in the intended patient population. Mathematical models describing the pharmacokinetic-pharmacodynamic (PK-PD) properties of a drug are valuable to increase the knowledge about drug effects and disease and can be used to inform decisions. READ MORE

7. 5. Simulation of additive manufacturing using a mechanism based plasticity model

   Author : Andreas Malmelöv; Andreas Lundbäck; Mathias Wallin; Luleå tekniska universitet; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Residual stress; Material model; Alloy 625; Alloy 718; deformations; Finite Element Method; synchrotron X-ray diffraction; Solid Mechanics; Hållfasthetslära;

   Abstract : This thesis presents finite element (FE) simulations of additive manufacturing (AM) and physically based material modeling of alloy 625 and alloy 718. In recent years, there has been an increasing interest in AM and there has been a dramatic increase in publications in the field. READ MORE