Search for dissertations about: "Med21"

Found 2 swedish dissertations containing the word Med21.

2. 1. Studies of Functional Interactions within Yeast Mediator and a Proposed Novel Mechanism for Regulation of Gene Expression

   Author : Magnus Hallberg; Stefan Björklund; Karl Ekwall; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Mediator; Transcriptional regulation; Srb10; Cdk8; Med2; Srb7; Med21; RNA pol II; Biokemi; Biochemistry; Biokemi; medicinsk biokemi; Medical Biochemistry;

   Abstract : The yeast Mediator complex is required for transcriptional regulation both in vivo and in vitro and the identification of similar complexes from metazoans indicates that its function is conserved through evolution. Mediator subunit composition and structure is well characterized both by biochemical, genetic and biophysical methods. READ MORE

4. 2. Dynamics of protein folding and subunit interactions in assembly of the yeast mediator complex

   Author : Zaki Shaikhibrahim; Stefan Björklund; Bengt-Harald Jonsson; Umeå universitet; []
   Keywords : mediator; transcriptional regulation; assembly; folding; MEDICINE; MEDICIN; medicinsk biokemi; Medical Biochemistry;

   Abstract : The Mediator complex was originally discovered in the yeast Saccharomyces cerevisiae and has since then been shown to be required for transcriptional regulation both in vitro and in vivo. The Mediator complex also stimulates basal, unregulated transcription and serves as a bridge by conveying signals from promoter-bound transcriptional regulatory proteins such as activators and repressors to the RNA Polymerase II general transcriptional machinery. READ MORE