Search for dissertations about: "Medicin och hälsovetenskap Medicinsk bioteknologi Biomedicinsk laboratorievetenskap teknologi"
Showing result 1 - 5 of 113 swedish dissertations containing the words Medicin och hälsovetenskap Medicinsk bioteknologi Biomedicinsk laboratorievetenskap teknologi.
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1. High-throughput screening using multicellular tumor spheroids to reveal and exploit tumor-specific vulnerabilities
Abstract : High-throughput drug screening (HTS) in live cells is often a vital part of the preclinical anticancer drug discovery process. So far, two-dimensional (2D) monolayer cell cultures have been the most prevalent model in HTS endeavors. However, 2D cell cultures often fail to recapitulate the complex microenvironments of in vivo tumors. READ MORE
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2. Assessment of Novel Molecular Prognostic Markers in Chronic Lymphocytic Leukemia
Abstract : The clinical course of chronic lymphocytic leukemia (CLL) is highly heterogeneous, which has prompted the search for biomarkers that can predict prognosis in this disease. The IGHV gene mutation status and certain genomic aberrations have been identified as reliable prognostic markers of clinical outcome for this disorder. READ MORE
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3. Assessment of microvascular and metabolic responses in the skin
Abstract : The general aim of this project was to develop experimental in vivo models that allow for minimally invasive investigations of responses in the skin to microvascular and metabolic provocations. The cutaneous microvasculature has emerged as a valuable model and been proposed to mirror the microcirculation in other organs. READ MORE
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4. Microfluidic Compartmentalization for Smart Materials, Medical Diagnostics and Cell Therapy
Abstract : The organisation of fluids in small compartments is ubiquitous in nature, such as in the cellular composition of all life. This work explores several engineering avenues where microscale fluid compartmentalization can bring novel material properties or novel functionality in life sciences or medicine. READ MORE
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5. Decision Support for Treatment of Patients with Advanced Parkinson’s Disease
Abstract : The overall aim of this thesis was to develop, deploy and evaluate new IT-based methods for supporting treatment and assessment of treatment of advanced Parkinson’s disease. In this condition a number of different motor and non-motor symptoms occur in episodes of varying frequency, duration and severity. READ MORE