Search for dissertations about: "Methylation potential"

Showing result 1 - 5 of 106 swedish dissertations containing the words Methylation potential.

  2. 1. DNA methylation signatures in precursor lymphoid neoplasms : with focus on clinical implications & the biology behind

    Author : Zahra Haider; Sofie Degerman; Magnus Hultdin; Göran Roos; Pieter van Vlierberghe; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Acute Lymphoblastic Leukemia; Lymphoma; T-ALL; BCP-ALL; T-LBL; DNA methylation; CIMP; Prognosis; TAL1; HOX.;

    Abstract : Precursor lymphoid neoplasms, namely acute lymphoblastic leukemias (ALL) and lymphoblastic lymphomas (LBL), are characterized by an aggressive proliferation of malignant progenitor B- or T-cells. To improve risk classification at diagnosis, better prognostic and treatment stratifying biomarkers are needed. READ MORE

  4. 2. DNA methylation profiling of CNS tumors; implications for clinical diagnostics

    Author : Sandra Ferreyra Vega; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Central nervous system tumors; DNA methylation; clinical diagnostics; diffuse gliomas; meningiomas; heterogeneity;

    Abstract : Diffuse gliomas and meningiomas are the most common primary tumors of the central nervous system (CNS) in adults and these tumors cause significant morbidity and mortality worldwide. Deregulation of the epigenetic mechanisms, e.g. READ MORE

  5. 3. Deregulated epigenetics and cancer stem cells in brain tumours

    Author : Anna Wenger; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer stem cell; glioblastoma; paediatric; methylation; heterogeneity; CRISPR;

    Abstract : Glioblastoma (GBM) is an incurable brain tumour with dismal prognosis as the median survival for afflicted patients is only 8 months. Aberrations of epigenetic processes, which govern gene expression, are involved in cancer, but these epigenetic mechanisms are reversible and can potentially be corrected by treatment. READ MORE

  6. 4. Molecular Epidemiology of Breast Cancer

    Author : Sophia Harlid; Malmö Klinisk mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast Cancer; Heritability; Methylation potential; CpG-SNPs; Common variants; Gene-environment interactions;

    Abstract : Hereditary breast cancer constitutes a considerable fraction of the total number of breast cancer cases occurring each year. Up until recently very few breast cancer predisposing genes were known, but many new common polymorphisms contributing to increased cancer susceptibility are continuously being identified. READ MORE

  7. 5. Unraveling the importance of thiol compounds on mercury speciation, uptake and transformation by the iron-reducer Geobacter sulfurreducens

    Author : Mareike Franziska Gutensohn; Erik Björn; Ulf Skyllberg; Jeffra K. Schaefer; Vera Slaveykova; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; mercury; low molecular mass thiols; speciation; uptake; methylation; reduction; Hg 0 ; Hg II ; MeHg; Geobacter sulfurreducens; ICP-MS; LC-MS MS; X-ray absorption spectroscopy; cell physiology;

    Abstract : The biogenic methylation of inorganic, divalent mercury (Hg(II)) by methylating microorganisms leads to formation and bioaccumulation of monomethyl mercury (MeHg) in the environment and can cause severe damage to ecosystems and human health. Diverse microorganisms carry the gene sequence hgcAB and are able to methylate Hg(II) intracellularly. READ MORE