Search for dissertations about: "Metyrapone"
Showing result 1 - 5 of 11 swedish dissertations containing the word Metyrapone.
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1. Taste Hedonics and the Intake of Alcohol and Food
Abstract : This thesis includes four papers based on animal experimental work. They analyze the way in which activation of a specific motivational state - hunger- modulates the rewarding actions of alcohol and taste palatability. READ MORE
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2. Allergen-induced late airways reaction in the pig : influence of endogenous and exogenous glucocorticoids
Abstract : A novel model for studies of the allergen-induced late reaction in the lower airways was developed in the pig. The influence on late bronchial obstruction and granulocyte function of endogenous cortisol levels and treatment with the glucocorticoid budesonide (BUD) was evaluated. READ MORE
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3. Adrenal Bioactivation and Toxicity of 3-MeSO2-DDE, o,p´-DDD and DMBA Investigated in Tissue Slice Culture
Abstract : I developed a precision-cut adrenal slice culture procedure to investigate cytochrome P450 (CYP) catalysed irreversible binding and adrenocorticolytic effects in human, rodent, and fish adrenal tissue, ex vivo. Autoradiography and radioluminography of exposed tissue slices showed that the potent adrenal toxicant 3-methylsulphonyl-2,2´-bis(4-chlorophenyl)-1,1´-dichloroethene (MeSO2-DDE) causes a selective metabolite binding in zona fasciculata (ZF), which is diminished by the CYP11B1 inhibitor metyrapone. READ MORE
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4. Improving maintenance treatment of heroin addiction : the role of buprenorphine
Abstract : Background: Heroin addiction is a condition with high morbidity and mortality. The discovery of Methadone Maintenance Treatment (MMT) by Dole and co-workers 1964 represented the first major advance in the treatment of this condition. Through the work of Gunne et al in Uppsala, MMT was implemented in Sweden already in 1966. READ MORE
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5. Modulation of the HPA axis alters the sensitivity of the cochlea to acoustic trauma
Abstract : The hypothalamic pituitary adrenal axis (HPA axis) regulates nearly all neuroendocrine responses of the body. An active HPA axis is crucial to maintaining homeostasis. An altered reactivity of the HPA axis can affect several physiological systems including the auditory system. READ MORE