Search for dissertations about: "Microglia activation"

Showing result 1 - 5 of 111 swedish dissertations containing the words Microglia activation.

2. 1. Altered cell signaling linked to neurodegeneration : Studies on scrapie-infected neuroblastoma cells and activated microglia

   Author : Christina Svensson; Tiit Land; Gianluigi Forloni; Stockholms universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prion disease; Inflammation; MAPK; Microglia activation; Neuroblastoma; Neurochemistry; Neurokemi; Neurochemistry and Neurotoxicology; neurokemi och neurotoxikologi;

   Abstract : Prion diseases are neurodegenerative disorders that can affect humans and animals. The underlying event is a conformational change of the normal cellular prion protein (PrPC) into an aberrant isoform termed PrP-scrapie (PrPSc). PrPSc is thought to lead to neurodegeneration and activation of glial cells. READ MORE

4. 2. Deciphering microglia plasticity in glioma

   Author : Dalel Saidi; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Microglia are the innate immune cells of the brain. One of the main characteristics of microglia is its extremely plasticity, which is necessary for them to deal with changing circumstances. Activation of microglia can contribute to contrasting effects by either proinflammatory, anti-inflammatory, or tumor-supportive phenotypes. READ MORE

5. 3. WNT signaling in microglia : WNTs as novel regulators of microglia

   Author : Carina Halleskog; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Microglia, the immunocompetent cells of the central nervous system (CNS) and the brain’s own macrophages are the most motile cells in the CNS and those with highest plasticity, as they rapidly move their projections to actively screen their environment for any type of injury. Upon cell damage or infection, microglia respond quickly: they proliferate, change morphology from ramified to amoeboid state to migrate or invade towards the injury, secrete many types of cytokines and chemokines to communicate with other inflammatory cells, and phagocytose cell debris. READ MORE

6. 4. The role of myeloid cells in neurodegenerative diseases. Studies on cellular phenotype and communication

   Author : Yiyi Yang; Neuroinflammation; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microglia; Neuroinflammation; Alzherimer’s disease; Stroke; Innate immune system; Systemic inflammation; Monocytes; Single-cell sequencing;

   Abstract : Neurological disorders are listed as the second leading cause of death worldwide. Stroke and Alzheimer’s disease (AD) are the major contributors to neurological disorders of deaths. Every year, around 14 million new people are affected by stoke and nearly 10 million new cases of AD are diagonosed worldwide. READ MORE

7. 5. The role of glial cells in alpha-synuclein pathology : Focus on degradation, cell-to-cell propagation and inflammation

   Author : Jinar Rostami; Anna Erlandsson; Martin Ingelsson; Joakim Bergström; Michael Heneka; Uppsala universitet; []
   Keywords : Parkinson’s disease; alpha-synuclein; amyloid-beta; astrocytes; microglia; tunneling nanotubes; antigen presentation; T cells; glial crosstalk; degradation; KYP-2407; Medicinsk vetenskap; Medical Science;

   Abstract : Growing evidence emphasizes the role of astrocytes and microglia in Parkinson’s disease (PD) and Alzheimer’s disease (AD). Yet, little is known about their impact on specific disease processes and if their involvement is beneficial or detrimental. READ MORE